MAPK 1

Pathways Recommended:	MAPK/ERK Pathway

By Targets:	p38 MAPK (7) Akt (3) ERK (1) FGFR (1) JNK (1) LIM Kinase (LIMK) (1) LPL Receptor (1) MAP3K (1) MMP (1) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (3) Src (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Targets Recommended: p38 MAPK MAP4K MNK MAPKAPK2 (MK2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent TAK1 inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, *MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1* and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines .

HY-P2456

*MBP MAPK* Substrate**	p38 MAPK	Others
MBP MAPK Substrate is used as an exogenous substrate for MAPK .

HY-N2232

N-Feruloyloctopamine	Akt p38 MAPK	Cancer
N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases the phosphorylation levels of Akt and *p38 MAPK* .

HY-RS08092

MAPK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAPK1 Human Pre-designed siRNA Set A MAPK1 Human Pre-designed siRNA Set A

HY-RS08093

Mapk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mapk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mapk1 Mouse Pre-designed siRNA Set A Mapk1 Mouse Pre-designed siRNA Set A

HY-RS08094

Mapk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mapk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mapk1 Rat Pre-designed siRNA Set A Mapk1 Rat Pre-designed siRNA Set A

HY-P0141

Akt/SKG Substrate Peptide	Akt	Others
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P0141A

Akt/SKG Substrate Peptide TFA	Akt	Others
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-N12726

Halociline	p38 MAPK MMP	Infection Inflammation/Immunology Cancer
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-152087

DCZ19931	ERK p38 MAPK	Cardiovascular Disease
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling .

HY-N3487

Isodorsmanin A	JNK p38 MAPK	Inflammation/Immunology
Isodorsmanin A is an anti-inflammatory agent. Isodorsmanin A suppresses the production of inflammatory mediators and proinflammatory cytokines. Isodorsmanin A inhibits the phosphorylation of JNK, *MAPK* .

HY-149921

Antiangiogenic agent 3	Others	Cancer
Antiangiogenic agent 3 (compound 3) is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilities. Antiangiogenic agent 3 also decreases the gene expression of Src, cdc42, and MAPK .

HY-10406

Talmapimod 3 Publications Verification SCIO-469	p38 MAPK	Cancer
Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs .

HY-10406A

Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	Cancer
Talmapimod (SCIO-469) hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs .

HY-13285

Ki16425 Maximum Cited Publications 8 Publications Verification Debio 0719	LPL Receptor	Neurological Disease Cancer
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K_is of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

Cat. No.	Product Name	Target	Research Area

HY-P2456

*MBP MAPK* Substrate**	p38 MAPK	Others
MBP MAPK Substrate is used as an exogenous substrate for MAPK .

HY-P0141

Akt/SKG Substrate Peptide	Akt	Others
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P0141A

Akt/SKG Substrate Peptide TFA	Akt	Others
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2232

N-Feruloyloctopamine	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Solanum lyratum Thunberg Phenols Polyphenols Solanaceae Plants Disease Research Fields Cancer	Akt p38 MAPK
N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases the phosphorylation levels of Akt and *p38 MAPK* .

HY-N12726

Halociline	Structural Classification Microorganisms Marine natural products Source classification Phenols Marine microorganism	p38 MAPK MMP
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-N3487

Isodorsmanin A	Structural Classification Chalcones Flavonoids Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	JNK p38 MAPK
Isodorsmanin A is an anti-inflammatory agent. Isodorsmanin A suppresses the production of inflammatory mediators and proinflammatory cytokines. Isodorsmanin A inhibits the phosphorylation of JNK, *MAPK* .

Species:	Human (3)
Tag:	His (2) GST (1) Flag (1)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75223

	ERK2 Protein, Human (sf9, His) Mitogen-activated protein kinase 1; MAPK 1; ERT1; ERK-2; p42-MAPK	Human	Sf9 insect cells
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. ERK2 Protein, Human (sf9, His) is the recombinant human-derived ERK2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P702903

	TNK1 Protein, Human (sf9, GST) CD38 Negative Kinase 1; Tyrosine Kinase Non Receptor 1; Mitogen-Activated Protein Kinase 1; MAPK1; CD36 Molecule; CD36; RAF1	Human	Sf9 insect cells
	TNK1 Protein, Human (sf9, GST) is the recombinant human-derived TNK1, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702735

	MAPK1 Protein, Human (Flag, His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPK; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80813

	Phospho-ERK1/2 (Thr202/Thr185) Antibody MAPK1/MAPK3	WB, IP	Human, Hamster, Rat
	Phospho-ERK1/2 (Thr202/Thr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Thr185). It can be used for WB,IP assays with tag free, in the background of Human, Hamster, Rat.

HY-P80815

	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody MAPK1/MAPK3	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42,44 kDa, targeting to Phospho-ERK1/2 (Tyr204/Tyr187). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80814

	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody MAPK1/MAPK3	WB	Human, Mouse, Rat
	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81156

	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.

HY-P81559

	*p44/42 MAPK* Antibody (YA1304)** MAPK1, MAPK3	WB	Human, Mouse, Rat
	p44/42 MAPK Antibody (YA1304) is a biotin-conjugated non-conjugated IgG antibody, targeting p44/42 MAPK, with a predicted molecular weight of 44/42 kDa (observed band size: 44/42 kDa). p44/42 MAPK Antibody (YA1304) can be used for WB experiment in human, mouse, rat background.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS08092

MAPK1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MAPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08093

Mapk1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Mapk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08094

Mapk1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Mapk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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