2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK p38 MAPK
  4. DCZ19931

DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling.

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DCZ19931 Chemical Structure

DCZ19931 Chemical Structure

CAS No. : 2789629-84-9

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DCZ19931 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

In Vitro

DCZ19931 (1 nM-10 μM; 24 h) shows no obvious cytotoxicity against human umbilical vein endothelial cells (HUVECs)[1].
DCZ19931 (500 nM; 24 h) suppresses (10 ng/mL; 12 h) VEGF-induced proliferation, migration, and tube formation ability of endothelial cells[1].
DCZ19931 (500 nM; 24 h) inhibits vascular permeability via downregulation of ICAM-1 expression[1].
DCZ19931 (500 nM; 24 h) reduces the expression levels of p-ERK1/2, p-p38, and p-JNK in HUVECs[1].
DCZ19931 also shows anti-angiogenic effects in mouse choroidal sprouting assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCZ19931 Related Antibodies

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 500 nM; with or without 50 ng/mL VEGF for 30 min
Incubation Time: 24 hours
Result: Decreased expression of phosphorylated ERK and phosphorylated p38.
In Vivo

DCZ19931 (1 μL, 1 μg/μL; intravitreal injection; single dose) inhibits ocular neovascularization in mice oxygen-induced retinopathy (OIR) model[1].
DCZ19931 (2 μL, 1 μg/μL; intravitreal injection; 7 d) has no tissue toxicity, and inhibits ocular neovascularization in mice with laser-induced choroidal neovascularization (CNV) model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Laser-induced choroidal neovascularization (CNV) model in mice[1]
Dosage: 2 μL, 1 μg/μL
Administration: Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation
Result: Did not cause marked histopathological changes in retinal structures.
Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo.
Animal Model: Oxygen-induced retinopathy (OIR) model in mice[1]
Dosage: 1 μL, 1 μg/μL
Administration: Intravitreal injection; single dose
Result: Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization.
Molecular Weight

549.45

Formula

C26H20F5N3O5
CAS No.
SMILES

COC1=CC(NC(C(F)(C2=CC=C(C=C2)OC3=C4C=C(C(OC)=CC4=NC=N3)OC)F)=O)=CC(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DCZ19931 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCZ199312789629-84-9DCZ 19931DCZ-19931ERKp38 MAPKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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