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Results for "

PIP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (2) DNA/RNA Synthesis (1) PI3K (5) TGF-β Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103224

PIT-1	PI3K	Cancer
PIT-1 is a selective *PIP3* (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .

HY-101562

Inavolisib 3 Publications Verification GDC-0077; RG6114	PI3K Apoptosis	Cancer
GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα .

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides	Akt TGF-β Receptor	Inflammation/Immunology
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses ^[3] .

HY-W127317

Inositol 1,3,4,5-tetraphosphate	Others	Others
Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate) .

HY-124348

DM-PIT-1 3,5-Dimethyl PIT-1	PI3K	Cancer
DM-PIT-1 is a **PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin)** interaction inhibitor . DM-PIT-1 has the potential for the research of ovarian cancer .

HY-165099

C-8 Ceramide-1-phosphate	Apoptosis PI3K DNA/RNA Synthesis	Metabolic Disease
C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate *PI3-K, which in turn produces PIP3; PIP3* can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

HY-106006

RV-1729	PI3K	Others Inflammation/Immunology
RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC₅₀=12 nM), showing twice the selectivity for PI3Kδ relative to PI3Kγ. RV-1729 is also 16 times more selective to PI3Kα. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kδ. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD) .

HY-148971A

PtdIns-(345)-P3 (12-dipalmitoyl) (sodium) Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium	Others	Others
PtdIns-(345)-P3 (12-dipalmitoyl) sodium (Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium) is a phosphatidylinositol 3,4,5-trisphosphate (PIP3) analog. PtdIns-(345)-P3 (12-dipalmitoyl) sodium can be incorporated in liposomes establish a backdrop of membrane phospholipids that closely mirrors in vivo conditions .

Cat. No.	Product Name	Type

HY-165099

C-8 Ceramide-1-phosphate	Drug Delivery
C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate *PI3-K, which in turn produces PIP3; PIP3* can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

C-8 Ceramide-1-phosphate

Drug Delivery

C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides	Animals Source classification	Akt TGF-β Receptor
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses ^[3] .

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