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PMSF

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0496
    PMSF
    80+ Cited Publications

    Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride

    		 Cathepsin Others
    PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.
    PMSF
  • HY-119352
    S-2 Methanandamide

    		Cannabinoid Receptor Neurological Disease
    S-2 Methanandamide is a potent CB1 receptor agonist, with IC50 values of 173 nM (with PMSF) and 8216 nM for CB1 and CB2, respectively .
    S-2 Methanandamide
  • HY-123594
    R-2 Methanandamide

    		Cannabinoid Receptor Neurological Disease
    R-2 Methanandamide (Compound 2) is a cannabinoid Anandamide (HY-10863) analog with a Ki of 119 nM for the cannabinoid receptor (Ki is determined using rat brain membranes with PMSF) .
    R-2 Methanandamide
  • HY-118222
    KBR 2822

    		Others Others
    KBR 2822 is an esterase inhibitor used to inhibit neuropathic target esterase (NTE), the target of delayed organophosphate-induced neuropathy. Experiments have shown that chronic oral administration of KBR-2822 (0.2 or 0.4 mg/kg/day) to chickens does not induce neuropathy and does not exacerbate toxic or traumatic axonopathy, even in the absence of intentional axonal injury. In the control group, administration of non-neuropathic Paraoxon (0.05 mg/kg/day orally) showed a mean AChE inhibition of 45% and no NTE inhibition. After chronic administration of KBR-2822, PMSF (120 mg/kg subcutaneously, 24 hours after the last KBR-2822 dose) was given, and KBR-2822-treated chickens did not develop neuropathy, while chickens treated with neuropathic DFP did. This suggests that sustained facilitatory "stress" is harmless to chicken axons in the absence of concurrent biochemical or neurotoxic insults.
    KBR 2822

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