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PPARα agonist-3

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By Targets:	PPAR (2) Reactive Oxygen Species (1)
By Research Areas:	Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

**PPARα agonist 3**	PPAR Reactive Oxygen Species	Inflammation/Immunology
PPARα agonist 3 (Compound A229) is a PPARα agonist (EC₅₀: 590 nM). PPARα agonist 3 inhibits TBHP or 4-HNE (HY-113466)-induced production of ROS .

**PPARα/γ agonist 3**	PPAR	Inflammation/Immunology
PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD) .

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