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Results for "

Polθ

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161302
    Polθ/PARP-IN-1

    		Apoptosis DNA/RNA Synthesis PARP Cancer
    Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity .
    Polθ/PARP-IN-1
  • HY-150279
    PolQi2

    		DNA/RNA Synthesis Others
    PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9, significantly improving the fidelity and performance of CRISPR/Cas9 gene editing. PolQi2 can be used in gene editing research .
    PolQi2
  • HY-145056
    ART615

    		Others Cancer
    ART615 is the related isomer of ART558. ART615, the inactive of ART558, elicits <10% Polθ inhibition at 12 µM, thus serving as a control for ART558 (IC50=7.9 nM) .
    ART615
  • HY-169285
    Polθ-IN-6

    		DNA/RNA Synthesis Cancer
    Polθ-IN-6 (Compound 89) is a DNA polymerase theta (Polθ) inhibitor. Polθ-IN-6 has antitumor activity .
    Polθ-IN-6
  • HY-169284
    Polθ-IN-5

    		DNA/RNA Synthesis Cancer
    Polθ-IN-5 (Compound 139) is a DNA polymerase theta (Polθ) inhibitor. Polθ-IN-5 has antitumor activity .
    Polθ-IN-5
  • HY-161916
    Polθ-IN-4

    		DNA/RNA Synthesis Cancer
    Polθ-IN-4 (Example 1) is a DNA polymerase theta (Polθ) inhibitor that inhibits Polθ activity by targeting its ATP-dependent helicase domain. Polθ-IN-4 can be utilized in cancer research .
    Polθ-IN-4
  • HY-158346
    Polθ-IN-3

    		DNA/RNA Synthesis Cancer
    Polθ-IN-3 (Compound 113) is an orally active inhibitor of Polymerase Theta (Polθ). Polθ-IN-3 has antitumor activity .
    Polθ-IN-3
  • HY-139593S
    Polθ-IN-1-d3

    		Isotope-Labeled Compounds Cancer
    Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670) .
    Polθ-IN-1-d3
  • HY-159078
    PolQi1

    		DNA/RNA Synthesis Cancer
    PolQi1 is a Polϴ (polymerase theta) inhibitor. PolQi1 targets the polymerase domain of the enzyme .
    PolQi1

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