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Secondary mutation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Caspase (1) Endogenous Metabolite (1) FLT3 (2) Isotope-Labeled Compounds (1) Parasite (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (5) Infection (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6615

Aflatoxin B1 4 Publications Verification	Apoptosis Reactive Oxygen Species Bcl-2 Family Caspase	Infection Cancer
Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects .

HY-N6615R

Aflatoxin B1 (Standard)	Bacterial Endogenous Metabolite Parasite	Infection Cancer
Aflatoxin B1 (Standard) is the analytical standard of Aflatoxin B1. This product is intended for research and analytical applications. Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation .

HY-N6615S

Aflatoxin B1-13C17	Isotope-Labeled Compounds	Cancer
Aflatoxin B1- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and Aspergillus parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects .

HY-158265

FLT3D835Y/F691L-IN-1	FLT3	Cancer
FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor of FLT3 3-tyrosine kinase domain D835Y/F691L secondary mutations with IC₅₀s of 1.5 and 9.7 nM. FLT3D835Y/F691L-IN-1 can be used for acute myeloid leukemia research .

HY-143434

FLT3/D835Y-IN-1	FLT3	Cancer
FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC₅₀ values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6615

Aflatoxin B1 4 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Apoptosis Reactive Oxygen Species Bcl-2 Family Caspase
Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects .

HY-N6615R

Aflatoxin B1 (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenylpropanoids Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Parasite
Aflatoxin B1 (Standard) is the analytical standard of Aflatoxin B1. This product is intended for research and analytical applications. Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation .

Cat. No.	Product Name	Chemical Structure

HY-N6615S

Aflatoxin B1-13C17
Aflatoxin B1- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and Aspergillus parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects .

Aflatoxin B1-13C17

Aflatoxin B1- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and Aspergillus parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects .

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