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Results for "

TLR1/2

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1180A
    Pam3CSK4 TFA
    Maximum Cited Publications
    11 Publications Verification

    Pam3Cys-Ser-(Lys)4 TFA

    		 Toll-like Receptor (TLR) Infection Inflammation/Immunology
    Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 [1].
    Pam3CSK4 TFA
  • HY-108471
    CU-CPT22
    5+ Cited Publications

    		 Toll-like Receptor (TLR) Cancer
    CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM [1].
    CU-CPT22
  • HY-110353
    CU-T12-9
    5 Publications Verification

    		 Toll-like Receptor (TLR) Inflammation/Immunology Cancer
    CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS [1].
    CU-T12-9
  • HY-P1180
    Pam3CSK4

    Pam3Cys-Ser-(Lys)4

    		 Toll-like Receptor (TLR) Infection Inflammation/Immunology
    Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 [1].
    Pam3CSK4
  • HY-P1405
    Pam3CSK4-Biotin

    Pam3Cys-Ser-(Lys)4-Biotin

    		 Toll-like Receptor (TLR) Infection Inflammation/Immunology
    Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist [1].
    Pam3CSK4-Biotin
  • HY-163829
    TLR2 agonist 1

    		Toll-like Receptor (TLR) NF-κB Cancer
    TLR2 agonist 1 (Compound R-7d) is an agonist for human toll-like receptor 2 (TLR 2) with an EC50 of 116 pM. TLR2 agonist 1 enhances NF-κB promoter activation through TLR2/TLR1 heterodimers .
    TLR2 agonist 1
  • HY-122566
    SMU127

    ZINC666243

    		 Others Cancer
    SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC50=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.
    SMU127

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