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Results for "

antipruritic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Calcium Channel (1) Cannabinoid Receptor (1) Histamine Receptor (16) Influenza Virus (3) Isotope-Labeled Compounds (1) Parasite (1) Potassium Channel (2) TRP Channel (2)
By Research Areas:	Cancer (6) Endocrinology (5) Infection (4) Inflammation/Immunology (16) Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107949

Flumethasone pivalate Flumethasone 21-pivalate; Locacorten; Locorten	Others	Inflammation/Immunology
Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities .

HY-12532

Astemizole 5 Publications Verification R 43512	Histamine Receptor Potassium Channel	Inflammation/Immunology Endocrinology
Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K ⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects .

HY-101189

JNJ-39758979	Histamine Receptor	Neurological Disease Endocrinology
JNJ-39758979 is a selective, orally active, and high-affinity histamine H₄ receptor antagonist with K_is of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H₄ receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity .

HY-13508

JNJ-7777120 1 Publications Verification	Histamine Receptor	Inflammation/Immunology
JNJ-7777120 is a potent and selective histamine H₄ receptor antagonist (K_i=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .

HY-B1607

Chlorphenoxamine 1 Publications Verification	Histamine Receptor	Neurological Disease Endocrinology
Chlorphenoxamine is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent.

HY-B1177

Crotamiton	Parasite	Infection
Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic.

HY-B0971

Pheniramine maleate Prophenpyridamine maleate; Tripoton maleate; Pheniramine maleate	Histamine Receptor Apoptosis	Inflammation/Immunology Endocrinology
Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-12532R

Astemizole (Standard)	Histamine Receptor Potassium Channel	Inflammation/Immunology Endocrinology
Astemizole (Standard) is the analytical standard of Astemizole. This product is intended for research and analytical applications. Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K ⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects .

HY-101189B

JNJ-39758979 dihydrochloride	Histamine Receptor	Inflammation/Immunology
JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H₄ receptor antagonist, with K_is of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H₄ receptor, respectively. JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride shows good anti-inflammatory and antipruritic activity .

HY-B0971A

Pheniramine Prophenpyridamine; Tripoton; Pheniramine solution	Histamine Receptor Apoptosis	Inflammation/Immunology Cancer
Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-B0878

Halobetasol (propionate) 1 Publications Verification BMY-30056; CGP-14458; Ulobetasol propionate	Others	Others
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.

HY-B0473

Tetracaine hydrochloride Amethocaine hydrochloride	Calcium Channel	Neurological Disease
Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca ²⁺ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-N0808

Camphor 2 Publications Verification (±)-Camphor	TRP Channel Influenza Virus	Infection Inflammation/Immunology Cancer
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

HY-12752AR

Alimemazine hemitartrate (Standard)	Histamine Receptor	Neurological Disease Inflammation/Immunology Cancer
Alimemazine hemitartrate (Standard) is the analytical standard of Alimemazine hemitartrate. This product is intended for research and analytical applications. Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.

HY-120541A

ST-1006 Maleate	Histamine Receptor	Inflammation/Immunology
ST-1006 maleate is a potent histamine H4 receptor agonist with a pK_i value of 7.94. ST-1006 maleate has anti-inflammatory effect .

HY-120541

ST-1006	Histamine Receptor	Inflammation/Immunology
ST-1006 is a potent histamine H4 receptor agonist with a pK_i value of 7.94. ST-1006 has anti-inflammatory effect .

HY-N0808R

Camphor (Standard)	TRP Channel Influenza Virus	Infection Inflammation/Immunology Cancer
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

HY-12752

Alimemazine Trimeprazine	Histamine Receptor	Neurological Disease Inflammation/Immunology
Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .

HY-145153

S-777469	Cannabinoid Receptor	Neurological Disease
S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a K_i of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism .

HY-101188

INCB38579	Histamine Receptor	Infection
INCB38579 is an orally active, highly brain penetrable, and selective histamine H₄ receptor (HH₄R) antagonist (hH₄R IC₅₀=4.8 nM, mH₄R IC₅₀=42 nM, rH₄R IC₅₀=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities .

HY-12752BS

Alimemazine-d6 hydrochloride Trimeprazine-d₆ hydrochloride	Histamine Receptor Isotope-Labeled Compounds	Neurological Disease Inflammation/Immunology Cancer
Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .

HY-147276

Izuforant JW1601	Histamine Receptor	Inflammation/Immunology
Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC₅₀ of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC₅₀ of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies .

HY-12752A

Alimemazine hemitartrate Trimeprazine hemitartrate	Histamine Receptor Influenza Virus	Neurological Disease Inflammation/Immunology Cancer
Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0808

Camphor 2 Publications Verification (±)-Camphor	Infection Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Plants Lauraceae Cinnamomum camphora Inflammation/Immunology Disease Research Fields	TRP Channel Influenza Virus
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

HY-N0808R

Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Source classification Plants Lauraceae Cinnamomum camphora	TRP Channel Influenza Virus
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .

Cat. No.	Product Name	Chemical Structure

HY-12752BS

Alimemazine-d6 hydrochloride
Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .

Alimemazine-d6 hydrochloride

Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties .

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