2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. ST-1006

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect.

For research use only. We do not sell to patients.

ST-1006 Chemical Structure

ST-1006 Chemical Structure

CAS No. : 1196994-11-2

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1 mg USD 240 In-stock
5 mg USD 600 In-stock
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50 mg USD 1950 In-stock
100 mg USD 2450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of ST-1006:

ST-1006 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

IC50 & Target[1]

H4 receptor

7.94 (pKi)

In Vitro

ST-1006 (10 μM) is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) suppresses FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ST-1006 Related Antibodies
In Vivo

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) has anti-inflammatory effect and displays an antipruritic effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1]
Dosage: 1-100 mg/kg
Administration: Subcutaneous injection
Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
Molecular Weight

367.28

Formula

C16H20Cl2N6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (340.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7227 mL 13.6136 mL 27.2272 mL
5 mM 0.5445 mL 2.7227 mL 5.4454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7227 mL 13.6136 mL 27.2272 mL 68.0680 mL
5 mM 0.5445 mL 2.7227 mL 5.4454 mL 13.6136 mL
10 mM 0.2723 mL 1.3614 mL 2.7227 mL 6.8068 mL
15 mM 0.1815 mL 0.9076 mL 1.8151 mL 4.5379 mL
20 mM 0.1361 mL 0.6807 mL 1.3614 mL 3.4034 mL
25 mM 0.1089 mL 0.5445 mL 1.0891 mL 2.7227 mL
30 mM 0.0908 mL 0.4538 mL 0.9076 mL 2.2689 mL
40 mM 0.0681 mL 0.3403 mL 0.6807 mL 1.7017 mL
50 mM 0.0545 mL 0.2723 mL 0.5445 mL 1.3614 mL
60 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1345 mL
80 mM 0.0340 mL 0.1702 mL 0.3403 mL 0.8508 mL
100 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6807 mL
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ST-1006 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-10061196994-11-2ST1006ST 1006Histamine Receptoranti-inflammatoryantipruriticbasophilsFceRIInhibitorinhibitorinhibit

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