ST-1006 Maleate

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ST-1006 maleate is a potent histamine H4 receptor agonist with a pK_i value of 7.94. ST-1006 maleate has anti-inflammatory effect.

For research use only. We do not sell to patients.

ST-1006 Maleate Chemical Structure

CAS No. : 1196994-12-3

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Other Forms of ST-1006 Maleate:

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Purity & Documentation
References
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Description

ST-1006 maleate is a potent histamine H4 receptor agonist with a pK_i value of 7.94. ST-1006 maleate has anti-inflammatory effect^[1]^[2].

In Vitro

ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils^[2].
ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)^[1]
Dosage:	1-100 mg/kg
Administration:	Subcutaneous injection
Result:	Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.

Molecular Weight

599.42

Formula

C₂₄H₂₈Cl₂N₆O₈

CAS No.

1196994-12-3

SMILES

OC(/C=C\C(O)=O)=O.ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2.OC(/C=C\C(O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [Content Brief]

[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. [Content Brief]

ST-1006 Maleate Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-10061196994-12-3ST1006ST 1006Histamine Receptoranti-inflammatoryantipruriticbasophilsFceRIInhibitorinhibitorinhibit

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