Alimemazine (Synonyms: Trimeprazine)

Cat. No.: HY-12752: FAQs
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Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Alimemazine hemitartrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Alimemazine Chemical Structure

CAS No. : 84-96-8

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Other In-stock Forms of Alimemazine:

Alimemazine hemitartrate

Other Forms of Alimemazine:

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Biological Activity
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Description	Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties^[1]^[2].
IC₅₀ & Target	HA receptor^[1]
Molecular Weight	298.45
Formula	C₁₈H₂₂N₂S
CAS No.	84-96-8
SMILES	CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C31
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. [Content Brief] [2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3). [Content Brief]

Alimemazine Related Classifications

Neurological Disease Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alimemazine84-96-8TrimeprazineHistamine Receptorhemagglutininhistamin-H1Inhibitorinhibitorinhibit

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