Crotamiton

Cat. No.: HY-B1177 Purity: 96.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic.

For research use only. We do not sell to patients.

Crotamiton Chemical Structure

CAS No. : 483-63-6

Size	Price	Stock	Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

or Bulk Inquiry

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This product is a controlled substance and not for sale in your territory.

Other Forms of Crotamiton:

Crotamiton-d₅ Get quote
Crotamiton (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic. It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite.

IC₅₀ & Target

Mite

Molecular Weight

203.28

Formula

C₁₃H₁₇NO

CAS No.

483-63-6

Appearance

<25°C Solid,>25°C Liquid

Color

Colorless to light yellow

SMILES

C/C=C/C(N(CC)C1=CC=CC=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 140 mg/mL (688.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 140 mg/mL (688.71 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9193 mL	24.5966 mL	49.1932 mL
5 mM	0.9839 mL	4.9193 mL	9.8386 mL
10 mM	0.4919 mL	2.4597 mL	4.9193 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.5 mg/mL (17.22 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.5 mg/mL (17.22 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.5 mg/mL (17.22 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.79%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (250 KB) HNMR (137 KB) RP-HPLC (208 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Kittaka H, et al. Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects. Pflugers Arch. 2017 Oct;469(10):1313-1323. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.9193 mL	24.5966 mL	49.1932 mL	122.9831 mL
	5 mM	0.9839 mL	4.9193 mL	9.8386 mL	24.5966 mL
	10 mM	0.4919 mL	2.4597 mL	4.9193 mL	12.2983 mL
	15 mM	0.3280 mL	1.6398 mL	3.2795 mL	8.1989 mL
	20 mM	0.2460 mL	1.2298 mL	2.4597 mL	6.1492 mL
	25 mM	0.1968 mL	0.9839 mL	1.9677 mL	4.9193 mL
	30 mM	0.1640 mL	0.8199 mL	1.6398 mL	4.0994 mL
	40 mM	0.1230 mL	0.6149 mL	1.2298 mL	3.0746 mL
	50 mM	0.0984 mL	0.4919 mL	0.9839 mL	2.4597 mL
	60 mM	0.0820 mL	0.4099 mL	0.8199 mL	2.0497 mL
	80 mM	0.0615 mL	0.3075 mL	0.6149 mL	1.5373 mL
	100 mM	0.0492 mL	0.2460 mL	0.4919 mL	1.2298 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Crotamiton Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crotamiton483-63-6ParasiteInhibitorinhibitorinhibit

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