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prostaglandin F2α analogs

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106916
    Unoprostone

    		Potassium Channel Neurological Disease
    Unoprostone, a prostaglandin F2α analogs (PGAs), activates BK channels to reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension .
    Unoprostone
  • HY-100571
    Cloprostenol isopropyl ester

    		Prostaglandin Receptor Endocrinology
    Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM .
    Cloprostenol isopropyl ester
  • HY-118599
    Prostaglandin F2α ethyl amide

    		Others Others
    Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .
    Prostaglandin F2α ethyl amide
  • HY-116549
    Prostaglandin F2α alcohol

    PGF2α alcohol

    		 Others Inflammation/Immunology
    Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist .
    Prostaglandin F2α alcohol
  • HY-124219
    17-Phenoxy trinor prostaglandin F2α ethyl amide

    17-Phenoxy trinor PGF2α ethyl amide

    		 Prostaglandin Receptor Others
    17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .
    17-Phenoxy trinor prostaglandin F2α ethyl amide
  • HY-118648
    Prostaglandin F2α methyl ester

    PGF2α methyl ester; Dinoprost methyl

    		 Others Others
    Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive .
    Prostaglandin F2α methyl ester
  • HY-158571
    17-Phenoxy trinor prostaglandin F2α

    17-Phenoxy trinor PGF2α

    		 Others Metabolic Disease Inflammation/Immunology
    17-Phenoxy trinor prostaglandin F2α is a PGF2α analog .
    17-Phenoxy trinor prostaglandin F2α
  • HY-158595
    15(R),19(R)-Hydroxy prostaglandin F2α

    15(R),19(R)-Hydroxy PGF2α

    		 Others Others
    15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen .
    15(R),19(R)-Hydroxy prostaglandin F2α
  • HY-149588
    17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester

    		Others Endocrinology
    17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester is an analog of PGF2α .
    17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester
  • HY-118190
    AL 8810 methyl ester

    		Prostaglandin Receptor Endocrinology
    AL 8810 methyl ester is a prostaglandin F(2α) analog and a prostaglandin F(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines .
    AL 8810 methyl ester
  • HY-120197
    17-Phenyl trinor prostaglandin F2α methyl amide

    		Others Endocrinology
    17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding .
    17-Phenyl trinor prostaglandin F2α methyl amide
  • HY-128428
    Carboprost

    15(S)-15-Methyl prostaglandin F2α; 15-Methyl-PGF2α

    		 Prostaglandin Receptor Endocrinology
    Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
    Carboprost
  • HY-132277
    15-Keto Bimatoprost

    		Others Endocrinology
    15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive .
    15-Keto Bimatoprost
  • HY-124243
    N-Cyclopropyl methyl bimatoprost

    17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide

    		 Prostaglandin Receptor Others
    N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .
    N-Cyclopropyl methyl bimatoprost
  • HY-128428R
    Carboprost (Standard)

    		Prostaglandin Receptor Endocrinology
    Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
    Carboprost (Standard)
  • HY-139124
    15(R)-15-Methyl Prostaglandin F2α

    15(R)-Carboprost; 15(R)-15-methyl PGF2α

    		 Others Metabolic Disease
    15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
    15(R)-15-Methyl Prostaglandin F2α
  • HY-W746888
    17-Phenyl trinor prostaglandin F2α diethyl amide

    17-p-PGF2α-NEt2; 17-Phenyl trinor PGF2α diethyl amide

    		 Prostaglandin Receptor Cardiovascular Disease
    17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF2α analog with hypotensive efficacy .
    17-Phenyl trinor prostaglandin F2α diethyl amide
  • HY-132277S
    15-Keto Bimatoprost-d5

    		Isotope-Labeled Compounds Others
    15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive[1][2].
    15-Keto Bimatoprost-d5
  • HY-163376
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide

    17-CF3PTPG2α EA

    		 Others Metabolic Disease
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α .
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide
  • HY-139063
    16-Phenoxy tetranor prostaglandin F2α

    16-Phenoxy tetranor PGF2α

    		 Others Metabolic Disease
    16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.
    16-Phenoxy tetranor prostaglandin F2α
  • HY-158937
    15(R)-15-Methyl prostaglandin F2α methyl ester

    15(R)-Methyl carboprost; 15(R)-15-Methyl PGF2α methyl ester

    		 Others Others
    15(R)-15-Methyl prostaglandin F2α methyl ester (15(R)-Methyl carboprost) (compound 15R) is a 15-methyl substituted prostaglandin analog, a member of the prostaglandin family, with potential biological activities in a variety of biological systems, but its specific activity mechanism and application details are not described in detail from the existing information.
    15(R)-15-Methyl prostaglandin F2α methyl ester
  • HY-124200
    AL 8810 isopropyl ester

    		Prostaglandin Receptor Endocrinology
    AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).
    AL 8810 isopropyl ester
  • HY-137544
    16-Phenyl tetranor Prostaglandin F2α

    16-Phenyl tetranor PGF2α

    		 Others Metabolic Disease
    16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
    16-Phenyl tetranor Prostaglandin F2α
  • HY-113756A
    Latanoprost acid
    1 Publications Verification

    		 Prostaglandin Receptor Inflammation/Immunology
    Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
    Latanoprost acid
  • HY-120982
    (+)-15-epi Cloprostenol

    		Prostaglandin Receptor Endocrinology
    Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However, the specific activity of this isomer has not been well studied.
    (+)-15-epi Cloprostenol
  • HY-114841
    ONO 207

    13,14-Dihydrodinoprost; 13,14-dihydro PGF2α

    		 Prostaglandin Receptor Endocrinology
    13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 μg/100 g.
    ONO 207
  • HY-113756AR
    Latanoprost acid (Standard)

    		Prostaglandin Receptor Inflammation/Immunology
    Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
    Latanoprost acid (Standard)
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α

    15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-137504
    20-ethyl Prostaglandin F2α

    ICI 74205; 20-ethyl PGF2α

    		 Prostaglandin Receptor Metabolic Disease
    20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone.noprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM).2 In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.
    20-ethyl Prostaglandin F2α

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