Adenosine 5'-diphosphate-¹⁵N₅ dilithium  (Synonyms: Adenosine diphosphate-¹⁵N₅ dilithium; ADP-¹⁵N₅ dilithium)

Adenosine 5'-diphosphate-¹⁵N₅ (Adenosine diphosphate-¹⁵N₅ dilithium; ADP-¹⁵N₅) dilithium is ¹⁵N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

444.03

C₁₀H₁₃Li₂¹⁵N₅O₁₀P₂

58-64-0

O[C@@H]1[C@H](O)[C@@H](COP(OP(O[Li])(O[Li])=O)(O)=O)O[C@H]1[15N]2C=[15N]C3=C([15NH2])[15N]=C[15N]=C32

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16.  [Content Brief]

  [3]. Noel J. Cusack, et al. Effects of phosphate-modified analogs of adenosine 5′-diphosphate and adenosine 5′‐triphosphate at P_2T-purinoceptors mediating human platelet activation by ADP. April 1996.

  [4]. Adenosine-5'-diphosphate