Asteltoxin

Cat. No.: HY-119665: FAQs
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Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation.

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Asteltoxin Chemical Structure

CAS No. : 79663-49-3

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Biological Activity
Purity & Documentation
References
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Description

Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation^[1].

In Vitro

Asteltoxin (1-100 μg/ml) inhibits the production of CD63-positive EV with IC₅₀ of 2.1 μg/ml and exhibits no significant cytotoxicity in HT29 cells^[1].
Asteltoxin (1-10 μg/ml) activates AMPK pathways and inhibits mTORC1 pathways by inducing a decrease in ATP level, therefore activates lysosome function and inhibits the EV secretion of cancer cells PC-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HT-29
Concentration:	1-100 μg/ml
Incubation Time:	24 h
Result:	Exhibited cytotoxicity with an IC₅₀ over 100 μg/ml.

Cell Proliferation Assay^[1]

Cell Line:	PC-3
Concentration:	1-10 μg/ml
Incubation Time:	3 days
Result:	Revealed no effect on anchorage-dependent growth of PC-3.

Western Blot Analysis^[1]

Cell Line:	PC-3
Concentration:	1-10 μg/ml
Incubation Time:	24 h
Result:	Increased levels of pAMPK Decreased levels of pS6K and p4E-BP1.

Molecular Weight

418.48

Formula

C₂₃H₃₀O₇

CAS No.

79663-49-3

SMILES

O=C1C=C(C(C)=C(O1)/C=C/C=C/C=C/[C@@H]2[C@@H]([C@]3(C)[C@@](O)([C@H](O[C@@]3(O2)[H])CC)C)O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mitani F,et al., Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. Sci Rep. 2022 Apr 23;12(1):6674. [Content Brief]

Asteltoxin Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asteltoxin79663-49-3AMPKmTORAMP-activated protein kinaseMammalian target of RapamycinHT29 colon cancer cellPC-3Inhibitorinhibitorinhibit

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