Relb - RELB proto-oncogene, NF-kB subunit Gene

Rattus norvegicus

Gene ID: 100360982 | Gene type: protein coding

About Relb

Primary_assembly 1: 79,257,725-79,285,507 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Spleen (RPKM 67.), Thymus (RPKM 49.5) and 9 other tissues.

Summary

Enables DNA binding activity. Involved in cellular response to osmotic stress. Located in nucleus. Used to study kidney disease; muscular atrophy; and ureteral obstruction. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in breast Cancer and immunodeficiency 53. Orthologous to human RelB (RelB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Relb Products(6)

mRNA	Protein	Name
XM_006228503.4	XP_006228565.1	transcription factor RelB isoform X2
XM_017590004.2	XP_017445493.1	transcription factor RelB isoform X4
XM_008759054.3	XP_008757276.1	transcription factor RelB isoform X5
XM_017590005.2	XP_017445494.1	transcription factor RelB isoform X4
XM_017590003.2	XP_017445492.1	transcription factor RelB isoform X3
XM_006228502.4	XP_006228564.1	transcription factor RelB isoform X1

Relb Protein Structure

RelB_leu_zip

RHD-n_RelB

RHD_dimer

RelB_transactiv

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

transcription factor RelB

avian reticuloendotheliosis viral (v-rel) oncogene related B	v-rel avian reticuloendotheliosis viral oncogene homolog B
v-rel reticuloendotheliosis viral oncogene homolog B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14645	(-)-DHMEQ	Inhibitor	99.37%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Relb	NCBI	NCBI:5971

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