RELB - RELB proto-oncogene, NF-kB subunit Gene

Homo sapiens

Also known as IREL; I-REL; IMD53; REL-B

Gene ID: 5971 | Gene type: protein coding

About RELB

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,001,464-45,038,192 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 14.1), appendix (RPKM 10.1) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast Cancer and immunodeficiency 53. Biomarker of breast Cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

RELB Products(6)

mRNA	Protein	Name
XM_047439190.1	XP_047295146.1	transcription factor RelB isoform X4
XM_047439189.1	XP_047295145.1	transcription factor RelB isoform X3
NM_006509.4	NP_006500.2	transcription factor RelB isoform 1
XM_005259128.3	XP_005259185.1	transcription factor RelB isoform X2
XM_005259127.4	XP_005259184.1	transcription factor RelB isoform X1
NM_001411087.1	NP_001398016.1	transcription factor RelB isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23729669	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	26385063	GOA
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22065573	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23729669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22065573	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	19158276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RELB Protein Structure

RHD_DNA_bind

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

transcription factor RelB

v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)

v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

RELB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RELB	Q01201	RELA	Homo sapiens	Q04206-2	Anti Tag CoIP	28514442
Intra	RELB	Q01201	NFKB1	Homo sapiens	P19838	Y2H	21988832
Intra	RELB	Q01201	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	33961781
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	33961781
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	TAP	14743216
Intra	RELB	Q01201	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	28514442
Intra	RELB	Q01201	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	33961781
Intra	RELB	Q01201	GSK3B	Homo sapiens	P49841	Protein Kinase Assay	21217772
Intra	RELB	Q01201	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	21217772

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Immunodeficiency 53

IMD53

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14645	(-)-DHMEQ	Inhibitor	99.47%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RELB	VGNC	VGNC:69284
Macaca mulatta	RELB	VGNC	VGNC:76894
Rattus norvegicus	RELB	RGD	RGD:2321078
Mus musculus	RELB	MGD	MGI:103289
Canis familiaris	RELB	VGNC	VGNC:45467
Bos taurus	RELB	VGNC	VGNC:33859
Others	RELB	NCBI

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