MMGT1 - membrane magnesium transporter 1 Gene

Homo sapiens

Also known as EMC5; TMEM32

Gene ID: 93380 | Gene type: protein coding

About MMGT1

This gene has 4 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.3), bone marrow (RPKM 10.9) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

MMGT1 Products(2)

mRNA	Protein	Name
NM_001330000.2	NP_001316929.1	ER membrane protein complex subunit 5 precursor
NM_173470.3	NP_775741.1	ER membrane protein complex subunit 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to membrane insertase activity	IMP IMP: Inferred from mutant phenotype	29809151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22119785	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IDA: Inferred from direct assay	29242231	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP IMP: Inferred from mutant phenotype	29809151	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	29242231	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	29242231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of EMC complex	IDA IDA: Inferred from direct assay	22119785	GOA
part of EMC complex	IPI IPI: Inferred from physical interaction	32439656	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32439656	GOA
located in membrane	IDA IDA: Inferred from direct assay	22119785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMGT1 Protein Structure

MMgT

0
100
131 a.a.

Protein Preferred Names

Protein Names

ER membrane protein complex subunit 5

transmembrane protein 32

Recombinant MMGT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77087	MMGT1 Protein, Human (HEK293, His)	Q8N4V1-1/NP_775741.1 (E66-R131)	≥95%

Related Diseases

Diseases

Alias

Chromosome 15q11.2 Deletion Syndrome

15q11.2 Microdeletion Syndrome	15q11.2 Bp1-Bp2 Microdeletion Syndrome
Del(15)(Q11.2)	Monosomy 15q11.2
15q11.2 Microdeletion	Chromosome 15q11.2 Deletion
Chromosome 15q11.2 Microdeletion	Chromosome Deletion Syndrome 15q11.2
Microdeletion 15q11.2	Duplication 15q11-Q13 Syndrome

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08515	MMGT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MMGT1	MGD	MGI:2384305
Felis catus	MMGT1	VGNC	VGNC:63536
Bos taurus	MMGT1	VGNC	VGNC:31516
Rattus norvegicus	MMGT1	RGD	RGD:1566339
Others	MMGT1	NCBI

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