MMGT1 Protein, Human (HEK293, His)

N-His;Accession#Q8N4V1-1/NP_775741.1 MMGT1 (E66-R131)

MMGT1 protein is an essential component of the endoplasmic reticulum membrane protein complex (EMC), playing a crucial role in the energy-independent insertion of newly synthesized membrane proteins into endoplasmic reticulum (ER) membranes. It exhibits a preference for accommodating proteins with transmembrane domains that possess weak hydrophobicity or contain destabilizing features, such as charged and aromatic residues. MMGT1 is actively involved in both cotranslational and post-translational insertion processes. In cotranslational insertion, it facilitates the proper positioning of N-terminal transmembrane domains in an N-exo topology, ensuring the translocated N-terminus resides in the ER lumen, particularly impacting the topology of multi-pass membrane proteins like G protein-coupled receptors. Moreover, MMGT1 indirectly influences various cellular processes by regulating the insertion of diverse proteins into membranes. Additionally, it is implicated in Mg(2+) transport and operates as a key constituent of the EMC.

Human

HEK293

N-His

Q8N4V1-1/NP_775741.1 (E66-R131)

93380  [NCBI]

23-29 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.