2. Academic Validation
  3. Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma

Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma

  • Hum Pathol. 2018 Nov;81:113-120. doi: 10.1016/j.humpath.2018.06.032.
Chengjun Sun 1,  Shanzhou Huang 1,  Weiqiang Ju 1,  Yuchen Hou 1,  Ziming Wang 1,  Youjie Liu 2,  Linwei Wu 3,  Xiaoshun He 4
Affiliations

Affiliations

  • 1 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
  • 2 Basic Medical College, Jinan University, Guangzhou, 510632, China.
  • 3 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: lw97002@163.com.
  • 4 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: gdtrc@163.com.
PMID: 30136646 DOI: 10.1016/j.humpath.2018.06.032
Abstract

Dosage suppressor of Nnf1 (DSN1) is a component of the kinetochore protein complex that is required for proper chromosome segregation. Some studies have explored that DSN1 is related to colorectal Cancer progression. However, the role of DSN1 in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore DSN1 expression in HCC tissues. We obtained data from The Cancer Genome Atlas and Gene Expression Omnibus to analyze DSN1 expression in HCC. DSN1 mRNA expression was assessed in 30 pairs of HCC samples via reverse-transcription quantitative polymerase chain reaction. Immunohistochemical analysis of 95 HCC tissue specimens was performed to assess DSN1 expression and examine the clinicopathological characteristics of DSN1 in HCC. Results showed that DSN1 was upregulated in HCC tissues and was strongly associated with sex (P = .031), α-fetoprotein (P < .001), tumor size (P = .032), tumor nodule number (P = .028), Cancer embolus (P = .011), and differentiation grade (P = .001). Moreover, Kaplan-Meier and COX proportional-hazards analyses indicated that high DSN1 expression was related to poor HCC patient survival and that DSN1 can serve as an independent prognostic factor for overall survival and disease-free survival. In conclusion, our findings indicate that DSN1 could serve as a novel prognostic biomarker for HCC patients.

Keywords

Cancer; DSN1; Hepatocellular carcinoma; Prognosis; Survival analysis.

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