2. Oligonucleotides
  3. mRNA

mRNA

mRNA—or messenger RNA—is a molecule that contains the instructions or recipe that directs the cells to make a protein using its natural machinery.Messenger RNAs (mRNAs) are a fast-emerging class of biotherapeutics. While they hold considerable promise, the field is still in its infancy. mRNA therapies offer a new opportunity for targeted treatment of challenging diseases and flexible manufacturing, as demonstrated by the rapid development of mRNA vaccines against COVID-19. The clinical potential of mRNA extends beyond vaccines to other advanced therapies, such as protein replacement, gene therapy, and cancer immunotherapy.

mRNA (316):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-153079
    eGFP mRNA(N1-Me-Pseudo UTP)
    The eGFP mRNA will express green fluorescent protein, originally isolated from the jellyfish, Aequorea victoria. The eGFP is a commonly used direct detection reporter in mammalian cell culture, yielding bright green fluorescence with an emission peak at 509 nm.
    eGFP mRNA(N1-Me-Pseudo UTP)
  • HY-153084
    CD19 CAR mRNA (Mouse)
    CD19 CAR mRNA (Mouse) expresses mouse CD19 CAR protein. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia.
    CD19 CAR mRNA (Mouse)
  • HY-153231
    eGFP mRNA-LNP
    eGFP mRNA-LNP is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability.
    eGFP mRNA-LNP
  • HY-153235
    COVID-19 Spike Protein mRNA-LNP
    COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2.
    COVID-19 Spike Protein mRNA-LNP
  • HY-153229
    Firefly luciferase mRNA-LNP
    Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency.
    Firefly luciferase mRNA-LNP
  • HY-150358
    β-galactosidase mRNA
    β-galactosidase mRNA encodes β-galactosidase, a protein product of the bacterial LacZ gene. β-galactosidase catalyzes the conversion of β-galactosides into monosaccharides which could be used as a common marker to assess transfection efficiency.
    β-galactosidase mRNA
  • HY-153084A
    CD19 CAR mRNA (Human)
    CD19 CAR mRNA (Human) expresses Human CD19 CAR protein. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia.
    CD19 CAR mRNA (Human)
  • HY-153083
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
    COVID-19 Spike Protein mRNA will express COVID-19 spike protein, and suitable for detection of RNA delivery, translation efficiency, cell viability, etc. COVID-19 spike protein is the novel coronavirus pneumonia spike protein located on the membrane surface. COVID-19 spike protein undertakes the functions of virus binding to host cell membrane receptors and membrane fusion, thereby mediating the entry of COVID-19 virus into cells. COVID-19 spike protein is an important site of action for host neutralizing antibodies and a key target for vaccine design.
    COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)
  • HY-153080
    Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
    Firefly luciferase mRNA will express a luciferase protein, originally isolated from the Photinus pyralis (Firefly). Firefly Luciferase is a frequently used bioluminescent reporter for gene regulation and function study. It is applicable in assays for gene expression, cell viability and in vivo imaging etc.
    Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
  • HY-174480
    Mouse Hand2 mRNA
    Mouse Hand2 mRNA encodes the mouse heart and neural crest derivatives expressed 2 (Hand2) protein, which is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.
    Mouse Hand2 mRNA
  • HY-174515
    Human TNFRSF1B mRNA
    Human TNFRSF1B mRNA encodes the human TNF receptor superfamily member 1B (TNFRSF1B) protein, a member of the TNF receptor superfamily.
    Human TNFRSF1B mRNA
  • HY-174516
    Human TNFRSF1A mRNA
    Human TNFRSF1A mRNA encodes the human TNF receptor superfamily member 1A (TNFRSF1A) protein, a member of the TNF receptor superfamily.
    Human TNFRSF1A mRNA
  • HY-174517
    Human TNFRSF14 mRNA
    Human TNFRSF14 mRNA encodes the human TNF receptor superfamily member 14 (TNFRSF14) protein, a member of the TNF receptor superfamily. TNFRSF14 functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells.
    Human TNFRSF14 mRNA
  • HY-174518
    Human TNF mRNA
    Human TNF mRNA encodes the human tumor necrosis factor (TNF) protein, a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
    Human TNF mRNA
  • HY-174519
    Human TLR9 mRNA
    Human TLR9 mRNA encodes the human toll like receptor 9 (TLR9) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR9 mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
    Human TLR9 mRNA
  • HY-174520
    Human TLR8 mRNA
    Human TLR8 mRNA encodes the human toll like receptor 8 (TLR8) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Human TLR8 mRNA
  • HY-174521
    Human TLR7 mRNA
    Human TLR7 mRNA encodes the human toll like receptor 7 (TLR7) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells.
    Human TLR7 mRNA
  • HY-174522
    Human TLR6 mRNA
    Human TLR6 mRNA encodes the human toll like receptor 6 (TLR6) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.
    Human TLR6 mRNA
  • HY-174523
    Human TLR5 mRNA
    Human TLR5 mRNA encodes the human toll like receptor 5 (TLR5) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes.
    Human TLR5 mRNA
  • HY-174524
    Human TLR4 mRNA
    Human TLR4 mRNA encodes the human toll like receptor 4 (TLR4) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR4 has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.
    Human TLR4 mRNA