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1422365-93-2

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136093A
    Lixumistat acetate

    IM156; HL156A; HL271 acetate

    		 Oxidative Phosphorylation AMPK Neurological Disease Cancer
    Lixumistat (IM156; HL156A; HL271) acetate, a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. Lixumistat (acetate) attenuates aging-associated cognitive impairment in animal model . Lixumistat (acetate) is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors .
    Lixumistat acetate
  • HY-136093B
    Lixumistat

    IM156 free base; HL156A free base; HL271 free base

    		 Mitochondrial Metabolism Cancer
    Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus .
    Lixumistat
  • HY-136093
    Lixumistat hydrochloride

    HL271; IM156 hydrochloride; HL156A hydrochloride

    		 Oxidative Phosphorylation AMPK Neurological Disease Cancer
    Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model . Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors .
    Lixumistat hydrochloride

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