3-IP

By Targets:	Apoptosis (1) Calcium Channel (1) Calmodulin (1) Mitochondrial Metabolism (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (7) siRNAs (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138620

MCU-i4 2 Publications Verification	Mitochondrial Metabolism	Metabolic Disease
MCU-i4 blocks the IP₃-dependent mitochondrial Ca ²⁺-uptake, maintaining the gatekeeping role of their target .

HY-NP135

Oxidized low density lipoprotein (Human) Human ox-LDL	NO Synthase NOD-like Receptor (NLR)	Metabolic Disease Inflammation/Immunology
Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate *NLRP3* inflammasome in macrophages .

HY-RS11313

PSMC3IP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PSMC3IP Human Pre-designed siRNA Set A contains three designed siRNAs for PSMC3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PSMC3IP Human Pre-designed siRNA Set A PSMC3IP Human Pre-designed siRNA Set A

HY-RS11562

RAB3IP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAB3IP Human Pre-designed siRNA Set A contains three designed siRNAs for RAB3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAB3IP Human Pre-designed siRNA Set A RAB3IP Human Pre-designed siRNA Set A

HY-RS06549

IER3IP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IER3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IER3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IER3IP1 Human Pre-designed siRNA Set A IER3IP1 Human Pre-designed siRNA Set A

HY-RS10535

PIK3IP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIK3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIK3IP1 Human Pre-designed siRNA Set A PIK3IP1 Human Pre-designed siRNA Set A

HY-RS14970

TRAF3IP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRAF3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRAF3IP1 Human Pre-designed siRNA Set A TRAF3IP1 Human Pre-designed siRNA Set A

HY-RS14971

TRAF3IP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRAF3IP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRAF3IP2 Human Pre-designed siRNA Set A TRAF3IP2 Human Pre-designed siRNA Set A

HY-RS14972

TRAF3IP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRAF3IP3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRAF3IP3 Human Pre-designed siRNA Set A TRAF3IP3 Human Pre-designed siRNA Set A

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca ²⁺ release .

HY-103312

Xestospongin C 3 Publications Verification (-)-Xestospongin C	Calcium Channel Apoptosis	Neurological Disease
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells ^[3].

Cat. No.	Product Name	Type

HY-W009458

3-Indoxyl phosphate sodium 3-IP sodium	Dyes
3-Indoxyl phosphate (3-IP) is a chromogenic and electrochemical substrate for alkaline phosphatase. Upon enzymatic cleavage by alkaline phosphatase, 3-indoxyl is released and subsequently oxidized to produce water-insoluble indigo, which can be quantified by colorimetric detection at 660 nm as a measure of alkaline phosphatase activity. 3-Indoxyl phosphate can also be converted to water-soluble leucoindigo by reduction of indigo in alkaline solution by sodium dithionite, which can be quantified by colorimetric detection at 415 nm or voltametric detection as a measure of alkaline phosphatase activity.2 3-Indoxyl phosphate has been used in ELISAs.

3-Indoxyl phosphate sodium

3-IP sodium

Dyes

3-Indoxyl phosphate (3-IP) is a chromogenic and electrochemical substrate for alkaline phosphatase. Upon enzymatic cleavage by alkaline phosphatase, 3-indoxyl is released and subsequently oxidized to produce water-insoluble indigo, which can be quantified by colorimetric detection at 660 nm as a measure of alkaline phosphatase activity. 3-Indoxyl phosphate can also be converted to water-soluble leucoindigo by reduction of indigo in alkaline solution by sodium dithionite, which can be quantified by colorimetric detection at 415 nm or voltametric detection as a measure of alkaline phosphatase activity.2 3-Indoxyl phosphate has been used in ELISAs.

Cat. No.	Product Name	Type

HY-NP135

Oxidized low density lipoprotein (Human) Human ox-LDL	Native Proteins
Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate *NLRP3* inflammasome in macrophages .

Oxidized low density lipoprotein (Human)

Human ox-LDL

Native Proteins

Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate NLRP3 inflammasome in macrophages .

Cat. No.	Product Name	Target	Research Area

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca ²⁺ release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103312

Xestospongin C 3 Publications Verification (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Structural Classification Animals Source classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells ^[3].

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71204

	PIK3IP1 Protein, Human (HEK293, His) Kringle domain-containing protein HGFL; PIK3IP1; HGFL	Human	HEK293
	PIK3IP1 protein acts as a potent negative regulator of phosphatidylinositol 3-kinase (PI3K) activity in the liver. It crucially modulates the PI3K signaling pathway, exerting inhibitory control over cellular processes influenced by PI3K. PIK3IP1's regulatory function emphasizes its significance in finely tuning intracellular signaling, particularly in hepatic processes where PI3K plays a central role in various cellular functions. PIK3IP1 Protein, Human (HEK293, His) is the recombinant human-derived PIK3IP1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77139

	PIK3IP1 Protein, Mouse (HEK293, His) Kringle domain-containing protein HGFL; PIK3IP1; HGFL	Mouse	HEK293
	The PIK3IP1 protein binds to the catalytic subunit of phosphatidylinositol 3-kinase. It negatively regulates phosphatidylinositol 3-kinase activity and signaling. PIK3IP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PIK3IP1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700539

	CXCR3 Protein, Human (Cell-Free, His) G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine C-X-C receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R	Human	E. coli Cell-free
	The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR3 protein, expressed by E. coli Cell-free , with C-10*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80673

	Fibrillarin Antibody FIB; FLRN; Nop1; RNU3IP1	WB, IP	Human, Mouse, Rat
	Fibrillarin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Fibrillarin. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81851

	IP3 Receptor Antibody (YA1596) 5-trisphosphate receptor; Inositol 1; InsP3R1; IP3; IP3 receptor; IP3R 1; IP3R; IP3R1; Itpr1; SCA15; SCA16; SCA29	WB	Human, Mouse, Rat
	IP3 Receptor Antibody (YA1596) is a biotin-conjugated non-conjugated IgG antibody, targeting IP3 Receptor, with a predicted molecular weight of 314 kDa. IP3 Receptor Antibody (YA1596) can be used for WB experiment in human, mouse, rat background.

HY-P81188

	CXCR3 Antibody CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.	WB	Human, Mouse, Rat
	CXCR3 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CXCR3 polyclonal antibody. CXCR3 Antibody can be used for: WB expriments in human, mouse, rat, and predicted: dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P83692

	CXCR3 Antibody (YA3426) CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.	WB, ICC/IF, IP	Human
	CXCR3 Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-CXCR3 monoclonal antibody. CXCR3 Antibody can be used for: WB expriments in human background without labeling.

HY-P82279

	SENP2 Antibody (YA2024) Axam2; Senp2; Sentrin specific protease 2; SMT3 specific isopeptidase 2; Smt3IP2	WB, IHC-P, ICC/IF	Human
	SENP2 Antibody (YA2024) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2024), targeting SENP2, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). SENP2 Antibody (YA2024) can be used for WB, IHC-P, ICC/IF experiment in human background.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS11313

PSMC3IP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PSMC3IP Human Pre-designed siRNA Set A contains three designed siRNAs for PSMC3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11562

RAB3IP Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
RAB3IP Human Pre-designed siRNA Set A contains three designed siRNAs for RAB3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06549

IER3IP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
IER3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IER3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10535

PIK3IP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PIK3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14970

TRAF3IP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRAF3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14971

TRAF3IP2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRAF3IP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14972

TRAF3IP3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRAF3IP3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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