CXCR3 Protein, Human (Cell-Free, His)

The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR3 protein, expressed by E. coli Cell-free , with C-10*His labeled tag.

The CXCR3 Protein functions as a receptor for the C-X-C chemokines CXCL9, CXCL10, and CXCL11, mediating the proliferation, survival, and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Additionally, it binds to CCL21, potentially promoting cell chemotaxis response. CXCR3 also serves as a receptor for the C-X-C chemokine CXCL4, playing a role in mediating the inhibitory activities of CXCL9, CXCL10, and CXCL11 on the proliferation, survival, and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Interestingly, CXCR3 does not promote cell chemotaxis response but, upon interaction with CXCL4 or CXCL10, activates the p38MAPK pathway, contributing to the inhibition of angiogenesis. Notably, overexpression of CXCR3 in renal cancer cells down-regulates the expression of the anti-apoptotic protein HMOX1 and promotes apoptosis, indicating its involvement in modulating cellular processes relevant to cancer biology.

Human

E. coli Cell-free

C-10*His

P49682-1 (M1-L368)

2833  [NCBI]

MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL

Monomer: 44 kDa Dimer: 90 KDa

Greater than 80% as determined by reducing SDS-PAGE.

/