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Results for "

53BP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

UNC9512	DNA/RNA Synthesis	Cancer
UNC9512 is a potent methyl-lysine reader p53 binding protein 1 (53BP1) antagonist. UNC9512 can be used to study the role of 53BP1 in DNA repair, gene editing and tumorigenesis .

UNC-2170	Others	Cancer
UNC-2170 is a functionally active, fragment-like ligand for *53BP1* (IC₅₀=29 µM; K_d=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) .

UNC3474	Others	Cancer
UNC3474 is a small molecule ligand, binding with *53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1* ^TT, with a dissociation constant (K_d) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells .

UNC-2170 maleate	DNA/RNA Synthesis	Cancer
UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein *53BP1, with IC₅₀* of 29 µM and K_d of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) .

TP53BP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53BP1 Human Pre-designed siRNA Set A TP53BP1 Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Application	Reactivity

	53BP1 Antibody 1 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	53BP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 214 kDa, targeting to TP53BP1. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

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TP53BP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TP53BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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