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  4. UNC3474

UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells.

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UNC3474 Chemical Structure

UNC3474 Chemical Structure

CAS No. : 1648707-79-2

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10 mg USD 260 In-stock
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50 mg USD 840 In-stock
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Based on 1 publication(s) in Google Scholar

UNC3474 Related Antibodies

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Description

UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1].

In Vitro

Unlike WT 53BP1TT, 53BP1TT-PN dose not interact with UNC3474[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC3474 Related Antibodies
Molecular Weight

276.42

Formula

C17H28N2O
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CC(C(C)C)=C1)NCCCNC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (361.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6177 mL 18.0884 mL 36.1768 mL
5 mM 0.7235 mL 3.6177 mL 7.2354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6177 mL 18.0884 mL 36.1768 mL 90.4421 mL
5 mM 0.7235 mL 3.6177 mL 7.2354 mL 18.0884 mL
10 mM 0.3618 mL 1.8088 mL 3.6177 mL 9.0442 mL
15 mM 0.2412 mL 1.2059 mL 2.4118 mL 6.0295 mL
20 mM 0.1809 mL 0.9044 mL 1.8088 mL 4.5221 mL
25 mM 0.1447 mL 0.7235 mL 1.4471 mL 3.6177 mL
30 mM 0.1206 mL 0.6029 mL 1.2059 mL 3.0147 mL
40 mM 0.0904 mL 0.4522 mL 0.9044 mL 2.2611 mL
50 mM 0.0724 mL 0.3618 mL 0.7235 mL 1.8088 mL
60 mM 0.0603 mL 0.3015 mL 0.6029 mL 1.5074 mL
80 mM 0.0452 mL 0.2261 mL 0.4522 mL 1.1305 mL
100 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
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UNC3474 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC34741648707-79-2UNC 3474UNC-3474OthersInhibitorinhibitorinhibit

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