ACAT1

Isoforms Recommended:	ACAT1

By Targets:	Acyltransferase (10) Apoptosis (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Metabolic Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13215

Avasimibe Maximum Cited Publications 9 Publications Verification CI-1011; PD-148515	Acyltransferase	Cancer
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for *ACAT1* and *ACAT2*, respectively ^[1]. Avasimibe can be used for the research of prostate cancer .

HY-100400A

K-604 dihydrochloride 2 Publications Verification	Acyltransferase	Cardiovascular Disease
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

HY-111880

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM ^[1].

HY-100399A

Nevanimibe hydrochloride 2 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride	Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer ^[1].

HY-100401A

Pactimibe sulfate CS-505	Acyltransferase	Cardiovascular Disease
Pactimibe sulfate (CS-505) is a dual *ACAT1/2* inhibitor with IC₅₀s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits *ACAT* with IC₅₀s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively ^[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a K_i value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC₅₀ of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .

HY-100401

Pactimibe CS-505 free base	Acyltransferase	Cardiovascular Disease
Pactimibe (CS-505 free base) is a dual *ACAT1/2* inhibitor with IC₅₀s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits *ACAT* with IC₅₀s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively ^[1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a K_i value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC₅₀ of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .

HY-RS00136

ACAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACAT1 Human Pre-designed siRNA Set A ACAT1 Human Pre-designed siRNA Set A

HY-RS00137

Acat1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acat1 Mouse Pre-designed siRNA Set A Acat1 Mouse Pre-designed siRNA Set A

HY-RS00138

Acat1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acat1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acat1 Rat Pre-designed siRNA Set A Acat1 Rat Pre-designed siRNA Set A

HY-100399

Nevanimibe PD-132301; ATR-101	Acyltransferase Apoptosis	Cancer
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer ^[1].

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-126455

Penicillide Vermixocin A	Acyltransferase	Metabolic Disease
Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) .

HY-118486

LDL-IN-1	Acyltransferase	Metabolic Disease
LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC₅₀ = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC₅₀s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111880

γ-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Natural Products Source classification Rutaceae Plants	Acyltransferase
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM ^[1].

HY-N10224

Terpendole C	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Indole Alkaloids	Acyltransferase
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-126455

Penicillide Vermixocin A	Monophenols Microorganisms Classification of Application Fields Source classification Phenols Metabolic Disease Disease Research Fields	Acyltransferase
Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P78986

	ACAT1 Protein, Human (His) Acetyl-CoA Acetyltransferase; THIL; ACAT; Acetyl-CoA Acetyltransferase, Mitochondrial; Acetyl-Coenzyme A Acetyltransferase; Acetoacetyl Coenzyme A Thiolase; Acetoacetyl-CoA Thiolase; EC 2.3.1.9; MAT; T2; Mitochondrial Acetoacetyl-CoA Thiolase; Testicular	Human	E. coli
	The ACAT1 protein is a key enzyme in mitochondrial beta-oxidation and plays a crucial role in breaking down fatty acids into acetyl-CoA. In the final step, ACAT1 catalyzes the thiolytic cleavage of 3-oxoacyl-CoA to generate acetyl-CoA and shortened fatty acyl-CoA. ACAT1 Protein Protein, Human (His) is the recombinant human-derived ACAT1 protein, expressed by E. coli , with N-His labeled tag. The total length of ACAT1 Protein, Human (His) is 394 a.a., with molecular weight of ~45 kDa.

HY-P78986A

	ACAT1 Protein Protein, Human Acetyl-CoA Acetyltransferase; THIL; ACAT; Acetyl-CoA Acetyltransferase, Mitochondrial; Acetyl-Coenzyme A Acetyltransferase; Acetoacetyl Coenzyme A Thiolase; Acetoacetyl-CoA Thiolase; EC 2.3.1.9; MAT; T2; Mitochondrial Acetoacetyl-CoA Thiolase; Testicular	Human	E. coli
	The ACAT1 protein is a key enzyme in mitochondrial beta-oxidation and plays a crucial role in breaking down fatty acids into acetyl-CoA. In the final step, ACAT1 catalyzes the thiolytic cleavage of 3-oxoacyl-CoA to generate acetyl-CoA and shortened fatty acyl-CoA. ACAT1 Protein Protein, Human is the recombinant human-derived ACAT1, expressed by E. coli , with tag Free labeled tag. The total length of ACAT1 Protein Protein, Human is 394 a.a.,

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HY-P82226

	ACAT1 Antibody (YA1971) T2; MAT; ACAT; THIL	WB, IP	Human
	ACAT1 Antibody (YA1971) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1971), targeting ACAT1, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). ACAT1 Antibody (YA1971) can be used for WB, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS00136

ACAT1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ACAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00137

Acat1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Acat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00138

Acat1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Acat1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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