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Isoforms Recommended: ADAM10
Results for "

ADAM10

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Peptides

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115670
    GW280264X
    3 Publications Verification

    		 MMP Inflammation/Immunology Cancer
    GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .
    GW280264X
  • HY-12636
    INCB3619

    		MMP Apoptosis Cancer
    INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity .
    INCB3619
  • HY-19956
    GI254023X
    Maximum Cited Publications
    12 Publications Verification

    GI4023; SRI028594

    		 MMP Cancer
    GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively.
    GI254023X
  • HY-110397
    KP-457
    3 Publications Verification

    		 MMP Cardiovascular Disease
    KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
    KP-457
  • HY-120852
    JG26

    		MMP Cancer
    JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively .
    JG26
  • HY-10293
    Aderbasib

    INCB007839; INCB7839

    		 MMP Cancer
    Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 + breast cancer, gliomas, et al .
    Aderbasib
  • HY-RS00265
    ADAM10 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAM10 Human Pre-designed siRNA Set A
    ADAM10 Human Pre-designed siRNA Set A
  • HY-RS00266
    Adam10 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Adam10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Adam10 Mouse Pre-designed siRNA Set A
    Adam10 Mouse Pre-designed siRNA Set A
  • HY-RS00267
    ADAM10 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAM10 Rat Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAM10 Rat Pre-designed siRNA Set A
    ADAM10 Rat Pre-designed siRNA Set A
  • HY-110397G
    KP-457 (GMP)

    		MMP Cardiovascular Disease
    KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .
    KP-457 (GMP)
  • HY-108675
    PPNDS tetrasodium

    		MMP P2X Receptor Infection Cancer
    PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers .
    PPNDS tetrasodium
  • HY-P3722
    Mca-PLAQAV-Dpa-RSSSR-NH2

    		Fluorescent Dye MMP Others
    Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
    Mca-PLAQAV-Dpa-RSSSR-NH2
  • HY-P3722A
    Mca-PLAQAV-Dpa-RSSSR-NH2 TFA

    		Fluorescent Dye MMP Others
    Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
    Mca-PLAQAV-Dpa-RSSSR-NH2 TFA

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