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Results for "

Blm

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Apoptosis (2) DNA/RNA Synthesis (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111756

BLM-IN-1	Apoptosis	Cancer
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a K_D valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC₅₀ value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer .

HY-12342

ML216 5 Publications Verification CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of *BLM* with a K_i of 1.76 µM. Antitumor avtivity .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-P3239

Belantamab mafodotin GSK2857916; Belantamab mafodotin-Blm	Antibody-Drug Conjugates (ADCs)	Cancer
Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity .

HY-110185

NSC 617145	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-156420

ATUX-1215	Others	Others
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

HY-151939

BLM-IN-2	DNA/RNA Synthesis Apoptosis	Cancer
BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC₅₀ value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC) .

HY-RS01520

BLM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BLM Human Pre-designed siRNA Set A contains three designed siRNAs for BLM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BLM Human Pre-designed siRNA Set A BLM Human Pre-designed siRNA Set A

HY-137992

Aucuparin	Others	Inflammation/Immunology
Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. Anti-inflammatory activity .

Cat. No.	Product Name	Target	Research Area

HY-P3239

Belantamab mafodotin GSK2857916; Belantamab mafodotin-Blm	Antibody-Drug Conjugates (ADCs)	Cancer
Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity .

Species:	Mouse (3)
Tag:	His (3) Myc (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76170

	BLMH/Bleomycin Hydrolase Protein, Mouse (His) Bleomycin hydrolase; BH; Blm hydrolase; BMH	Mouse	E. coli
	Bleomycin Hydrolase Protein (BLMH) is crucial for cellular defense, inactivating the antitumor drug Bleomycin (BLM) by hydrolyzing its carboxamide bond. This neutralizes BLM's cytotoxic effects, protecting normal and malignant cells. BLMH's exact physiological function is unknown, but its significance in maintaining cellular balance and defending against harmful agents is evident. BLMH/Bleomycin Hydrolase Protein, Mouse (His) is the recombinant mouse-derived BLMH/Bleomycin Hydrolase Protein, expressed by E. coli , with N-His labeled tag.

HY-P700626

	BLMH/Bleomycin Hydrolase Protein, Mouse (P. pastoris, His) Bleomycin hydrolase; BH; Blm hydrolase; BMH	Mouse	P. pastoris
	Bleomycin Hydrolase Protein (BLMH) is crucial for cellular defense, inactivating the antitumor drug Bleomycin (BLM) by hydrolyzing its carboxamide bond. This neutralizes BLM's cytotoxic effects, protecting normal and malignant cells. BLMH's exact physiological function is unknown, but its significance in maintaining cellular balance and defending against harmful agents is evident. BLMH/Bleomycin Hydrolase Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived BLMH/Bleomycin Hydrolase Protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72105

	BLM Protein, Mouse (His-Myc) BlmBloom syndrome protein homolog; mBlm; EC 3.6.4.12; RecQ helicase homolog	Mouse	E. coli
	BLM is an ATP-dependent DNA helicase that can unwind single- and double-stranded DNA in the 3'-5' direction and actively participates in the DNA replication and repair process. Notably, BLM plays a critical role in 5' end resection during double-strand break repair, recruiting DNA2 to cleave 5'-ssDNA. BLM Protein, Mouse (His-Myc) is the recombinant mouse-derived BLM protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of BLM Protein, Mouse (His-Myc) is 176 a.a., with molecular weight of ~24.7 kDa.

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BLM Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
BLM Human Pre-designed siRNA Set A contains three designed siRNAs for BLM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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