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Results for "

Cdc20

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130841
    Apcin-A

    		APC Ligands for Target Protein for PROTAC Cancer
    Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257) .
    Apcin-A
  • HY-110287
    Apcin
    5 Publications Verification

    		 APC Cancer
    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .
    Apcin
  • HY-100341
    M2I-1

    		Others Others
    M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC) .
    M2I-1
  • HY-130257
    CP5V

    		PROTACs Cancer
    CP5V is a PROTAC connected by ligands for von Hippel-Lindau and CDK, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation .
    CP5V
  • HY-13255
    TAME

    		APC Cancer
    TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable .
    TAME
  • HY-13255A
    TAME hydrochloride

    		APC Cancer
    TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable .
    TAME hydrochloride
  • HY-RS02288
    CDC20 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CDC20 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC20 Human Pre-designed siRNA Set A
    CDC20 Human Pre-designed siRNA Set A
  • HY-161257
    CDC20-IN-1

    		Autophagy Cancer
    CDC20-IN-1 (Compound E1) is a specific inhibitor of CDC20 and can be used in triple-negative breast cancer research. CDC20-IN-1 can induce autophagy in cancer cells and inhibit MDA-MB-231 cell proliferation, with an IC50 value of 1.43 μM .
    CDC20-IN-1
  • HY-RS02289
    CDC20B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CDC20B Human Pre-designed siRNA Set A contains three designed siRNAs for CDC20B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC20B Human Pre-designed siRNA Set A
    CDC20B Human Pre-designed siRNA Set A
  • HY-W614725
    Apcin-A monohydrochloride

    		APC Ligands for Target Protein for PROTAC Cancer
    Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257) .
    Apcin-A monohydrochloride
  • HY-131959
    (S,R,S)-AHPC-PEG5-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V .
    (S,R,S)-AHPC-PEG5-Boc
  • HY-116006
    Bis-PEG5-acid

    PROTAC Linker 36

    		 PROTAC Linkers Cancer
    Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20 .
    Bis-PEG5-acid

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