2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG5-Boc

(S,R,S)-AHPC-PEG5-Boc 

Cat. No.: HY-131959 Purity: 95.29% ee.: 100%(de)
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(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG5-Boc Chemical Structure

(S,R,S)-AHPC-PEG5-Boc Chemical Structure

CAS No. : 2923734-82-9

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG5-Boc Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V[1].

IC50 & Target[1]

VHL

 

Molecular Weight

807.01

Formula

C40H62N4O11S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(C)[C@@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)NC(CCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (123.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2391 mL 6.1957 mL 12.3914 mL
5 mM 0.2478 mL 1.2391 mL 2.4783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2391 mL 6.1957 mL 12.3914 mL 30.9786 mL
5 mM 0.2478 mL 1.2391 mL 2.4783 mL 6.1957 mL
10 mM 0.1239 mL 0.6196 mL 1.2391 mL 3.0979 mL
15 mM 0.0826 mL 0.4130 mL 0.8261 mL 2.0652 mL
20 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5489 mL
25 mM 0.0496 mL 0.2478 mL 0.4957 mL 1.2391 mL
30 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
40 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7745 mL
50 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6196 mL
60 mM 0.0207 mL 0.1033 mL 0.2065 mL 0.5163 mL
80 mM 0.0155 mL 0.0774 mL 0.1549 mL 0.3872 mL
100 mM 0.0124 mL 0.0620 mL 0.1239 mL 0.3098 mL
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(S,R,S)-AHPC-PEG5-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG5-Boc2923734-82-9E3 Ligase Ligand-Linker ConjugatesmitoticprogressioncancercellAPC/CdegradationInhibitorinhibitorinhibit

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