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Cilobradine

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18940A
    Cilobradine hydrochloride

    DK-AH 269

    		 HCN Channel Cardiovascular Disease
    Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
    Cilobradine hydrochloride
  • HY-18940
    Cilobradine

    Cilo

    		 Others Cardiovascular Disease
    Cilobradine (Cilo) is a HCN channel blocker with heart rate reducing activity. Cilobradine blocks the slow inward current of human HCN1, HCN2, HCN3, and HCN4 channels. Cilobradine has a slightly higher efficiency in blocking endogenous If in mouse sinoatrial node cells (IC50 value is 0.62μM). Cilobradine can dose-dependently reduce the heart rate from 600 to 200 bpm with an ED50 value of 1.2 mg/kg. Cilobradine induces arrhythmias at doses greater than 5 mg/kg, which are characterized by periodic fluctuations between T waves and P waves .
    Cilobradine

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