2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. Cilobradine hydrochloride

Cilobradine hydrochloride  (Synonyms: DK-AH 269)

Cat. No.: HY-18940A Purity: 98.85%
COA Handling Instructions

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Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.

For research use only. We do not sell to patients.

Cilobradine hydrochloride Chemical Structure

Cilobradine hydrochloride Chemical Structure

CAS No. : 186097-54-1

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1 mg USD 40 In-stock
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 320 In-stock
50 mg USD 512 In-stock
100 mg USD 820 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cilobradine hydrochloride:

Cilobradine hydrochloride Related Antibodies

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Description

Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. Target: HCN Channel blocker Cilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4).

Clinical Trial
Molecular Weight

519.07

Formula

C28H39ClN2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C[C@@H]2CN(CCC3=CC=C(OC)C(OC)=C3)CCC2)CCC4=CC(OC)=C(OC)C=C4C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (240.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (192.65 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9265 mL 9.6326 mL 19.2652 mL
5 mM 0.3853 mL 1.9265 mL 3.8530 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (247 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9265 mL 9.6326 mL 19.2652 mL 48.1631 mL
5 mM 0.3853 mL 1.9265 mL 3.8530 mL 9.6326 mL
10 mM 0.1927 mL 0.9633 mL 1.9265 mL 4.8163 mL
15 mM 0.1284 mL 0.6422 mL 1.2843 mL 3.2109 mL
20 mM 0.0963 mL 0.4816 mL 0.9633 mL 2.4082 mL
25 mM 0.0771 mL 0.3853 mL 0.7706 mL 1.9265 mL
30 mM 0.0642 mL 0.3211 mL 0.6422 mL 1.6054 mL
40 mM 0.0482 mL 0.2408 mL 0.4816 mL 1.2041 mL
50 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9633 mL
60 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.8027 mL
80 mM 0.0241 mL 0.1204 mL 0.2408 mL 0.6020 mL
100 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4816 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cilobradine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cilobradine186097-54-1DK-AH 269HCN ChannelHyperpolarization activated cyclic nucleotide gated channelsInhibitorinhibitorinhibit

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