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Results for "

Clonidine

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12721
    Clonidine
    5 Publications Verification

    		 Adrenergic Receptor Neurological Disease Cancer
    Clonidine is an alpha 2-adrenergic agonist .
    Clonidine
  • HY-B0409A
    Clonidine hydrochloride
    5 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
    Clonidine hydrochloride
  • HY-12721S
    Clonidine-d4 hydrochloride

    		Isotope-Labeled Compounds Adrenergic Receptor Neurological Disease
    Clonidine-d4 (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist[1].
    Clonidine-d4 hydrochloride
  • HY-12721R
    Clonidine (Standard)

    		Adrenergic Receptor Neurological Disease Cancer
    Clonidine (Standard) is the analytical standard of Clonidine. This product is intended for research and analytical applications. Clonidine is an alpha 2-adrenergic agonist .
    Clonidine (Standard)
  • HY-B0409AR
    Clonidine hydrochloride (Standard)

    		Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
    Clonidine hydrochloride (Standard)
  • HY-B0409S
    Clonidine-d4

    		Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Clonidine-d4 is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent[1][2][3][4][5].
    Clonidine-d4
  • HY-132423S
    4-Hydroxy Clonidine-d4

    		Isotope-Labeled Compounds Others
    4-Hydroxy Clonidine-d4 is the deuterium labeled 4-Hydroxy Clonidine[1].
    4-Hydroxy Clonidine-d4
  • HY-N8671
    Withanoside V

    		Others Neurological Disease
    Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .
    Withanoside V
  • HY-N8671R
    Withanoside V (Standard)

    		Others Neurological Disease
    Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .
    Withanoside V (Standard)
  • HY-121312
    Flutonidine

    ST-600

    		 Adrenergic Receptor Cardiovascular Disease
    Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides .
    Flutonidine
  • HY-155297
    Nebidrazine

    FLA-136

    		 Histamine Receptor Cardiovascular Disease
    Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation .
    Nebidrazine
  • HY-136693
    L-654284

    		Others Neurological Disease
    L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a Ki of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .
    L-654284
  • HY-B2195
    Aldioxa

    		Others Metabolic Disease
    Aidioxa has the ability to improve delayed gastric emptying in rats. It can partially improve delayed gastric emptying caused by clonidine or restraint stress. The allyltoin part of Aidioxa restores gastric emptying activity by antagonizing α-2 adrenergic receptors. Its aluminum hydroxide part is involved in restoring gastric compliance. Aidioxa can improve both delayed gastric emptying and impaired gastric compliance, both of which play an important role in functional dyspepsia (FD). Aidioxa is a candidate agent for inhibiting FD.
    Aldioxa
  • HY-12716
    BRL-44408

    		Adrenergic Receptor Endocrinology
    BRL-44408 is a selective adrenergic receptor antagonist of α2A/α2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K +-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing α2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337). BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by α2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release .
    BRL-44408

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