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EGFR-IN-119

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163880
    EGFR-IN-119

    		EGFR Ras p38 MAPK Reactive Oxygen Species Cancer
    EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC50 of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC50 of 1.34 μM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential .
    EGFR-IN-119

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