1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway GPCR/G Protein NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  2. EGFR Ras p38 MAPK Reactive Oxygen Species
  3. EGFR-IN-119

EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC50 of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC50 of 1.34 μM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential.

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EGFR-IN-119 Chemical Structure

EGFR-IN-119 Chemical Structure

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Description

EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC50 of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC50 of 1.34 μM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential[1].

Molecular Weight

469.52

Formula

C25H19N5O3S

SMILES

COC1=C(C(OC)=CC(C2=NC3=C(N4C2=NC(C#N)=C4/N=C/C5=CSC=C5)C=CC=C3)=C1)OC

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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EGFR-IN-119
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HY-163880
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