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Results for "

FANCD2

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126539
    UBE2T/FANCL-IN-1

    		E1/E2/E3 Enzyme Cancer
    UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .
    UBE2T/FANCL-IN-1
  • HY-153365
    I-138

    		Deubiquitinase Cancer
    I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
    I-138
  • HY-123834
    FEN1-IN-1
    4 Publications Verification

    		 FLAP ATM/ATR Cancer
    FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg 2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers .
    FEN1-IN-1
  • HY-14520
    Tetrahydrofolic acid
    1 Publications Verification

    L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid

    		 Endogenous Metabolite Metabolic Disease
    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
    Tetrahydrofolic acid
  • HY-RS04735
    FANCD2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FANCD2 Human Pre-designed siRNA Set A contains three designed siRNAs for FANCD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FANCD2 Human Pre-designed siRNA Set A
    FANCD2 Human Pre-designed siRNA Set A
  • HY-14520A
    (6S)-Tetrahydrofolic acid

    (6S)-5,6,7,8-Tetrahydrofolic acid

    		 Endogenous Metabolite Metabolic Disease
    (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .
    (6S)-Tetrahydrofolic acid
  • HY-14520B
    Tetrahydrofolic acid trihydrochloride

    L-5,6,7,8-Tetrahydrofolic acid trihydrochloride; L-Tetrahydrofolic acid trihydrochloride

    		 Endogenous Metabolite Metabolic Disease
    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) trihydrochloride is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid trihydrochloride is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid trihydrochloride serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
    Tetrahydrofolic acid trihydrochloride

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