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Results for "

GEM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (1) DNA/RNA Synthesis (2) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (3) Integrin (1) MDM-2/p53 (1) Nucleoside Antimetabolite/Analog (1) PKA (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (8) Infection (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) Antisense Oligonucleotides (5) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149906C

Trecovirsen sodium GEM91 sodium	HIV	Infection
Trecovirsen sodium is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.

HY-146540

GEM-5	HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53	Cancer
GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC₅₀=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth .

HY-145441

GEM–IB	Others	Cancer
GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS) .

HY-143411

GEM144	HDAC Apoptosis DNA/RNA Synthesis	Cancer
GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts .

HY-149906

Trecovirsen GEM91	HIV	Infection
Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.

HY-148827A

GEM-231 sodium HYBO-165 sodium	PKA	Cancer
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-148827

GEM-231 HYBO-165	PKA	Cancer
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-RS05366

GEM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GEM Human Pre-designed siRNA Set A contains three designed siRNAs for GEM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GEM Human Pre-designed siRNA Set A GEM Human Pre-designed siRNA Set A

HY-154843

C-Gem	Others	Cancer
C-Gem is a control molecule of S-Gem (HY-154842). C-Gem is completely inactive under experimental conditions .

HY-154842

S-Gem	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis	Cancer
S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine .

HY-149906A

FITC-Trecovirsen sodium FITC-GEM91 sodium	HIV	Infection
FITC-Trecovirsen (sodium) is a FITC labeled Trecovirsen. Trecovirsen is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene .

HY-145314

TC113	Integrin	Cancer
TC113 is a c(RGDyK)-Based conjugate of Gemcitabine (GEM). TC113 could be internalized by A549 cells through integrin α_vβ₃. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701847

	GEMIN6 Protein, Human GEMIN6; GEM-associated protein 6; GEMin-6; SIP2	Human	E. coli
	The GEMIN6 protein is a component of the SMN complex and is critical for the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential for spliceosome-mediated pre-mRNA splicing. Most spliceosomal snRNPs share a common set of Sm proteins that form a heptameric protein ring on small nuclear RNAs. GEMIN6 Protein, Human is the recombinant human-derived GEMIN6 protein, expressed by E. coli , with tag free. The total length of GEMIN6 Protein, Human is 167 a.a., .

HY-P701848

	GEMIN6 Protein, Human (His, Strep) GEMIN6; GEM-associated protein 6; GEMin-6; SIP2	Human	E. coli
	The GEMIN6 protein is a component of the SMN complex and is critical for the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential for spliceosome-mediated pre-mRNA splicing. Most spliceosomal snRNPs share a common set of Sm proteins that form a heptameric protein ring on small nuclear RNAs. GEMIN6 Protein, Human (His, Strep) is the recombinant human-derived GEMIN6 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of GEMIN6 Protein, Human (His, Strep) is 167 a.a., .

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HY-P81394

	Geminin Antibody (YA1139) GEM; GEMinin; GMNN	IHC-P	Human
	Geminin Antibody (YA1139) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1139), targeting Geminin. Geminin Antibody (YA1139) can be used for IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-149906C

Trecovirsen sodium GEM91 sodium		Antisense Oligonucleotides
Trecovirsen sodium is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.

HY-149906

Trecovirsen GEM91		Antisense Oligonucleotides
Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.

HY-148827A

GEM-231 sodium HYBO-165 sodium		Antisense Oligonucleotides
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-148827

GEM-231 HYBO-165		Antisense Oligonucleotides
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-RS05366

GEM Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
GEM Human Pre-designed siRNA Set A contains three designed siRNAs for GEM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-149906A

FITC-Trecovirsen sodium FITC-GEM91 sodium		Antisense Oligonucleotides
FITC-Trecovirsen (sodium) is a FITC labeled Trecovirsen. Trecovirsen is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene .

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