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LC3B

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By Targets:	Apoptosis (1) Atg7 (2) Atg8/LC3 (5) ATTECs (2) AUTACs (2) Autophagy (8) p62 (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

11

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

3

Antibodies

2

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DC-LC3in-D5	Atg8/LC3 Autophagy	Infection Inflammation/Immunology Cancer
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC₅₀ of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy .

ATG7-IN-2	Atg7 Autophagy	Cancer
ATG7-IN-2 (compound 1) is a potent ATG7 inhibitor, with an IC₅₀ of 0.089 μM. ATG7-IN-2 inhibits autophagy marker LC3B .

ATG7-IN-3	Atg7 Atg8/LC3 Autophagy	Cancer
ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC₅₀ of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4 .

CA-5f	p62 Atg8/LC3 Autophagy Apoptosis	Cancer
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .

LC3-mHTT-IN-AN1	Atg8/LC3 ATTECs Autophagy	Neurological Disease
LC3-mHTT-IN-AN1 (Compound AN1) is a *mHTT-LC3* linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

LC3-mHTT-IN-AN2	Atg8/LC3 ATTECs Autophagy	Neurological Disease
LC3-mHTT-IN-AN2 (Compound AN2) is a *mHTT-LC3* linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons .

AUTAC1	AUTACs Autophagy	Metabolic Disease Cancer
AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2 .

MAP1LC3B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAP1LC3B Human Pre-designed siRNA Set A contains three designed siRNAs for MAP1LC3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP1LC3B Human Pre-designed siRNA Set A MAP1LC3B Human Pre-designed siRNA Set A

MAP1LC3B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAP1LC3B2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP1LC3B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP1LC3B2 Human Pre-designed siRNA Set A MAP1LC3B2 Human Pre-designed siRNA Set A

(1R)-cis-Bifenthrin	Others	Others
(1R)-cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R)-cis-Bifenthrin has a significant impact on the motor function of ParK_in-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R)-cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R)-cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R)-cis-Bifenthrin has a lower binding energy with transferrin and transferrin receptor 2, showing stronger interactions. The biological effects of (1R)-cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways .

AUTAC2	AUTACs Autophagy	Inflammation/Immunology Cancer
AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .

Cat. No.	Compare	Product Name	Species	Source

	MAP1LC3B Protein, Human Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light cha	Human	E. coli
	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

	LC3B Antibody MAP1LC3B	WB, ICC/IF, IHC-F, IHC-P	Human, Mouse, Rat
	LC3B Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 15 kDa, targeting to LC3B. It can be used for WB,ICC/IF,IHC-F,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

	LC3B Antibody (YA308)	WB, IP	Human
	LC3B Antibody (YA308) is a non-conjugated and Rabbit origined monoclonal antibody about 14/16 kDa, targeting to LC3B. It can be used for WB,IP assays with tag free, in the background of Human.

	LC3A/B Antibody LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3; MAP1LC3A; LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3; MAP1LC3B	WB	Human, Mouse, Rat
	LC3A/B Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 14 kDa, targeting to LC3A/B. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

MAP1LC3B Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MAP1LC3B Human Pre-designed siRNA Set A contains three designed siRNAs for MAP1LC3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP1LC3B2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MAP1LC3B2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP1LC3B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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