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Results for "

NPM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Infection (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162265A

UCM-13369 dihydrochloride	Apoptosis	Cancer
UCM-13369 (Compound 4b) is a *NPM1* inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells. UCM-13369 can be used for leukemia research ^[1].

HY-136360

MI-3454 2 Publications Verification	Epigenetic Reader Domain	Cancer
MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC₅₀ of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis ^[1].

HY-N10264

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Antibiotic	Infection Cancer
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively ^[1] .

HY-RS09490

NPM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPM1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPM1 Human Pre-designed siRNA Set A NPM1 Human Pre-designed siRNA Set A

HY-162265

UCM-13369	Apoptosis	Cancer
UCM-13369 (Compound 4b) is a *NPM1* inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML ^[1].

HY-164279

YTR107	DNA/RNA Synthesis	Cancer
YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization ^[1] .

HY-114162B

VTP50469 mesylate	Others	Cancer
VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLL's chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10264

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Antibiotic
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively ^[1] .

Species:	Human (2) Mouse (1)
Tag:	His (3) SUMO (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P74680

	*Nucleophosmin/Npm1* Protein, Human (193a.a, His)** NPM1; Nucleophosmin; NPM; Numatrin	Human	E. coli
	The nucleophosmin/Npm1 protein plays critical roles in ribosome biogenesis, centrosome duplication, protein chaperones, histone assembly, and cell proliferation. Npm1 is a key player in the cellular orchestra that promotes ribosome nuclear export, associates with nucleolar ribonucleoprotein structures, and interacts with single-stranded nucleic acids. Nucleophosmin/Npm1 Protein, Human (193a.a, His) is the recombinant human-derived Nucleophosmin/Npm1 protein, expressed by E. coli , with N-His labeled tag.

HY-P74681

	*Nucleophosmin/Npm1* Protein, Human (150a.a, His)** NPM1; Nucleophosmin; NPM; Numatrin	Human	E. coli
	The nucleophosmin/Npm1 protein plays critical roles in ribosome biogenesis, centrosome duplication, protein chaperones, histone assembly, and cell proliferation. Npm1 is a key player in the cellular orchestra that promotes ribosome nuclear export, associates with nucleolar ribonucleoprotein structures, and interacts with single-stranded nucleic acids. Nucleophosmin/Npm1 Protein, Human (150a.a, His) is the recombinant human-derived Nucleophosmin/Npm1 protein, expressed by E. coli , with N-His labeled tag.

HY-P71574

	*Nucleophosmin/Npm1* Protein, Mouse (His-SUMO)** NPM1; Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin	Mouse	E. coli
	The nucleophosmin/Npm1 protein is a multifunctional nucleolar phosphoprotein involved in multiple cellular processes, including ribosome assembly and transport, DNA repair, and centrosome duplication.It plays a crucial role in maintaining genome stability and regulating cell proliferation.Nucleophosmin/Npm1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Nucleophosmin/Npm1 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

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NPM1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NPM1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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