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Results for "

PI5P4K

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153789
    PI5P4Kγ-IN-1

    		Others Cancer
    PI5P4Kγ-IN-1 (compound 2) is a selective PI5P4Kγ inhibitor. PI5P4Kγ-IN-1 can be used to signal mTORC1 in MCF-7 breast cancer cells and further characterize PI5P4Kγ in the cells .
    PI5P4Kγ-IN-1
  • HY-153531
    PI5P4Kα-IN-1

    		PI5P4K Metabolic Disease Inflammation/Immunology Cancer
    PI5P4Kα-IN-1 (Compound 13) is a PI5P4Kinhibitor (IC50: 2 and 9.4 μM for PI5P4Kα and PI5P4Kβ). PI5P4Kα-IN-1 can be used for research of cancer, metabolic and immunological disorders .
    PI5P4Kα-IN-1
  • HY-153526
    PI5P4Ks-IN-2

    		PI5P4K Others
    PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively .
    PI5P4Ks-IN-2
  • HY-136351
    THZ-P1-2
    2 Publications Verification

    		 Autophagy Cancer
    THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines .
    THZ-P1-2
  • HY-149659
    ARUK2007145

    		Others Cancer
    ARUK2007145 is potent, cell-active dual inhibitor of the PI5P4Kα and PI5P4Kγ isoforms (pIC50: 7.3 and 8.1, respectively) .
    ARUK2007145
  • HY-149423
    PI5P4K-β-IN-1

    		Others Others
    PI5P4K-β-IN-1 (compound vs1) is a potent inhibitor of PI5P4K-β (IC50: 0.80 μM) .
    PI5P4K-β-IN-1
  • HY-149424
    PI5P4K-β-IN-2

    		Others Cancer
    PI5P4K-β-IN-2 (compound d5) is a PI5P4K-β inhibitor (IC50=0.35 μM) with antitumor activity.
    PI5P4K-β-IN-2
  • HY-153529
    PI5P4Ks-IN-3

    		Others Cancer
    PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with IC50s of 1.34 μM (PI5P4Kα)，and 9.9 μM (PI5P4Kβ)，respectively. PI5P4Ks-IN-3 shows weak cellular activity .
    PI5P4Ks-IN-3
  • HY-145689
    PI5P4Ks-IN-1

    		PI5P4K Others
    PI5P4Ks-IN-1 (compound 7) is an active compound with no detectable inhibition of the PI5P4K α or β isoforms .
    PI5P4Ks-IN-1
  • HY-153532
    CVM-05-002

    		Others Cancer
    CVM-05-002 is a PI5P4K inhibitor, with IC50 values of 0.27 μM and 1.7 μM for PI5P4Kα and PI5P4Kβ, respectively .
    CVM-05-002
  • HY-139188
    CC260

    		PI5P4K Metabolic Disease Cancer
    CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research .
    CC260
  • HY-101423
    NIH-12848

    		PI5P4K Cardiovascular Disease
    NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
    NIH-12848
  • HY-152155
    ARUK2001607

    		PI5P4K Inflammation/Immunology Cancer
    ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases .
    ARUK2001607
  • HY-135680
    I-OMe-Tyrphostin AG 538

    I-OMe-AG 538

    		 IGF-1R Metabolic Disease Cancer
    I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM .
    I-OMe-Tyrphostin AG 538

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