2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PI5P4K

PI5P4K

PIP4K

PI5P4K/PIP4K (phosphatidylinositol 5-phosphate 4-kinase) is a crucial enzyme in phosphoinositide metabolism, with three isoforms: PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, encoded by the genes PIP4K2A, PIP4K2B, and PIP4K2C, respectively. These kinases phosphorylate phosphatidylinositol 5-phosphate (PI5P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), which is vital for various signaling pathways. PI5P4Ks modulate the levels of PI(4,5)P2 at intracellular membranes, essential for processes like endocytosis. The balance between PI5P and PI(4,5)P2 is critical for cellular responses to stress.
PI5P4Ks are involved in key signaling pathways, particularly the Hippo pathway, which regulates cell growth. the Hippo pathway kinases phosphorylated and suppressed the activity of PI5P4Ks. These two important evolutionarily conserved signaling pathways are integrated to regulate metazoan development and human disease. In cancer biology, PI5P4Ks exhibit dual roles. For instance, in prostate cancer, higher expression levels of PI5P4Kα correlate with lower androgen receptor signaling, suggesting a potential tumor-suppressive role 3. Conversely, in other contexts, they may promote tumor growth by enhancing survival pathways under stress conditions. The intricate balance of their activity could provide therapeutic targets for cancer treatment by manipulating these signaling pathways.

PI5P4K Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139868
    BAY-091
    		Inhibitor 99.55%
    BAY-091 is a novel potent and highly selective inhibitor of the kinase PIP4K2A.
    BAY-091
  • HY-101423
    NIH-12848
    		Inhibitor 99.84%
    NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
    NIH-12848
  • HY-139188
    CC260
    		Inhibitor 99.21%
    CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research.
    CC260
  • HY-153531
    PI5P4Kα-IN-1
    		Inhibitor 98.49%
    PI5P4Kα-IN-1 (Compound 13) is a PI5P4Kinhibitor (IC50: 2 and 9.4 μM for PI5P4Kα and PI5P4Kβ). PI5P4Kα-IN-1 can be used for research of cancer, metabolic and immunological disorders.
    PI5P4Kα-IN-1
  • HY-152155
    ARUK2001607
    		Inhibitor 99.73%
    ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases.
    ARUK2001607
  • HY-153526
    PI5P4Ks-IN-2
    		Inhibitor 99.78%
    PI5P4Ks-IN-2 is a inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Ks-IN-2 targets to PI5P4K isoforms with pIC50 values of <4.3 (PI5P4Kα), <4.6 (PI5P4Kβ), 6.2 (PI5P4Kγ), 0.32 (PI5P4Kγ+), respectively.
    PI5P4Ks-IN-2
  • HY-145689
    PI5P4Ks-IN-1
    		Inhibitor
    PI5P4Ks-IN-1 (compound 7) is an active compound with no detectable inhibition of the PI5P4K α or β isoforms.
    PI5P4Ks-IN-1
  • HY-153532
    CVM-05-002
    		Inhibitor
    CVM-05-002 is a PI5P4K inhibitor, with IC50 values of 0.27 μM and 1.7 μM for PI5P4Kα and PI5P4Kβ, respectively.
    CVM-05-002