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Results for "

PTK7

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Inhibitory Antibodies

1

Natural
Products

6

Recombinant Proteins

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160488
    PTK7/β-catenin-IN-1

    		β-catenin Cancer
    PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .
    PTK7/β-catenin-IN-1
  • HY-160493
    PTK7/β-catenin-IN-6

    		Wnt β-catenin Cancer
    PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .
    PTK7/β-catenin-IN-6
  • HY-160489
    PTK7/β-catenin-IN-2

    		β-catenin Cancer
    PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM .
    PTK7/β-catenin-IN-2
  • HY-P99829
    Cofetuzumab pelidotin

    PF-06647020; ABBV-647; h6M24-vc0101

    		 Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin Cancer
    Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
    Cofetuzumab pelidotin
  • HY-RS11404
    PTK7 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PTK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PTK7 Human Pre-designed siRNA Set A
    PTK7 Human Pre-designed siRNA Set A

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