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Results for "

PU.1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

3

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W176171
    PU.1-IN-1

    		Others Inflammation/Immunology
    PU.1-IN-1 (compound A11) is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 has anti-inflammatory properties [1].
    PU.1-IN-1
  • HY-124629
    DB2313
    1 Publications Verification

    		 Apoptosis Cancer
    DB2313 is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects [1].
    DB2313
  • HY-135797A
    DB1976 dihydrochloride
    4 Publications Verification

    		 Apoptosis Cancer
    DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect [1] .
    DB1976 dihydrochloride
  • HY-124676A
    DB2115 tertahydrochloride
    1 Publications Verification

    		 Apoptosis Cancer
    DB2115 (tertahydrochloride) is a potent inhibitor of myeloid master regulator PU.1. DB2115 (tertahydrochloride) has the potential for researching cancers, including hematologic cancers such as leukemia, as well as other conditions associated with PU. 1 dysfunction (extracted from patent WO2017223260A1, compound DB2115) [1].
    DB2115 tertahydrochloride
  • HY-124629A
    DB2313 tetrahydrochloride

    		Apoptosis Cancer
    DB2313 tetrahydrochloride is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of PU.1 with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects [1].
    DB2313 tetrahydrochloride
  • HY-135797
    DB1976

    		Apoptosis Cancer
    DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 has apoptosis-inducing effect [1] .
    DB1976

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