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Results for "

Pan-RAS

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101295
    Pan-RAS-IN-1
    5 Publications Verification

    		 Ras Cancer
    Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
    Pan-RAS-IN-1
  • HY-157887
    ADT-007

    		Ras Cancer
    ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects. ADT-007 binds RAS in a nucleotide-free conformation to block GTP activation. ADT-007 potently and selectively inhibits the growth of cancer cells with mutated or hyper-activated wild-type RAS isozymes .
    ADT-007
  • HY-118208
    ML-097
    1 Publications Verification

    CID-2160985

    		 Ras Cancer
    ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7 .
    ML-097
  • HY-124306
    ML-099
    2 Publications Verification

    CID-888706

    		 Ras Cancer
    ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A .
    ML-099
  • HY-163594
    Pan-RAS-IN-3

    		Ras Cancer
    Pan-RAS-IN-3 is a pan-Ras inhibitor, and can be used for study of melanoma and acute myeloid leukaemia .
    Pan-RAS-IN-3
  • HY-163595
    Pan-RAS-IN-4

    		Ras Cancer
    Pan-RAS-IN-4 (compound 2) is a potent inhibitor of RAS, with the IC50 of ＜ 100 nM for KRAS G12D. Pan-RAS-IN-4 plays an important rile in cancer research .
    Pan-RAS-IN-4
  • HY-162536
    Pan-RAS-IN-5

    		Molecular Glues Cyclophilin Ras Cancer
    Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects .
    Pan-RAS-IN-5
  • HY-158409
    Pan-RAS-IN-2

    		Molecular Glues Ras Cyclophilin Cancer
    Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects .
    Pan-RAS-IN-2
  • HY-168012
    DUSP6-IN-1

    		Ras Phosphatase Cancer
    DUSP6-IN-1 (compound 24) is an inhibitor targeting DUSP6, with IC50 values of 1.3 nM, 4.7 nM and 0.3 nM for KRAS G12C, G12D and G12V, respectively; IC50 values of 7 nM, 32 nM, 38 nM and 35 nM for the interaction of KRAS G12V, WT KRAS, WT HRAS and WT NRAS-BRAF with CYPA, respectively; IC50 values of 9.7 nM, 49.5 nM and 7.1 nM for KRAS-BRAF and CYPA under G12C, G12D and G12V, respectively; when inhibiting pERK, IC50 values for G12C and G12V are less than 0.6 nM, andIC50value for G12D is 0.9 nM .
    DUSP6-IN-1

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