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Results for "

Rheb

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124798
    Rheb inhibitor NR1
    2 Publications Verification

    		 mTOR Neurological Disease Inflammation/Immunology Cancer
    Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity .
    (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
    Rheb inhibitor NR1
  • HY-14530
    Pelitrexol
    1 Publications Verification

    AG 2037

    		 Antifolate Cancer
    Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice .
    Pelitrexol
  • HY-RS11942
    RHEB Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RHEB Human Pre-designed siRNA Set A contains three designed siRNAs for RHEB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RHEB Human Pre-designed siRNA Set A
    RHEB Human Pre-designed siRNA Set A

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