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Two-site molecular glue

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163944
    LL-K12-18

    		Molecular Glues CDK Cancer
    LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research .
    LL-K12-18

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