LL-K12-18

Cat. No.: HY-163944 Purity: 98.42%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC₅₀=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research.

For research use only. We do not sell to patients.

LL-K12-18 Chemical Structure

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

559.49

Formula

C₂₅H₃₂Cl₂N₁₀O

Appearance

Solid

Color

White to off-white

SMILES

CCN1C=NC2=C1N=C(N(CC3)CCN3C(CN(CC)CC)=O)N=C2NCC4=NC5=CC(Cl)=C(C=C5N4)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (44.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7873 mL	8.9367 mL	17.8734 mL
5 mM	0.3575 mL	1.7873 mL	3.5747 mL
10 mM	0.1787 mL	0.8937 mL	1.7873 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.42%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (252 KB) HNMR (151 KB) RP-HPLC (246 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Zemin Zhang, et al. "Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex." Nature Communications 15.1 (2024): 6477. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7873 mL	8.9367 mL	17.8734 mL	44.6836 mL
	5 mM	0.3575 mL	1.7873 mL	3.5747 mL	8.9367 mL
	10 mM	0.1787 mL	0.8937 mL	1.7873 mL	4.4684 mL
	15 mM	0.1192 mL	0.5958 mL	1.1916 mL	2.9789 mL
	20 mM	0.0894 mL	0.4468 mL	0.8937 mL	2.2342 mL
	25 mM	0.0715 mL	0.3575 mL	0.7149 mL	1.7873 mL
	30 mM	0.0596 mL	0.2979 mL	0.5958 mL	1.4895 mL
	40 mM	0.0447 mL	0.2234 mL	0.4468 mL	1.1171 mL

LL-K12-18 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LL-K12-18Molecular GluesCDKCyclin dependent kinaseTwo-site molecular glueCDK12DDB1anti-proliferationcancercyclin KInhibitorinhibitorinhibit

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