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Results for "

eIF2B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Eukaryotic Initiation Factor (eIF) (4) GSK-3 (2) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (1) Neurological Disease (6)
Oligonucleotides:	Pre-designed siRNA Sets (5) siRNAs (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12495A

ISRIB 10+ Cited Publications	Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF)	Neurological Disease
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of *eIF2B* and recovering the translation, and thus can be used for neurological disorders research ^[2] .

HY-158201

ATF4-IN-1	Eukaryotic Initiation Factor (eIF)	Neurological Disease
ATF4-IN-1 (Compound 21) is an ATF4 inhibitor and also an *eIF2B* activator. ATF4-IN-1 can be used in research on neurodegenerative diseases .

HY-125021

2BAct 1 Publications Verification	Eukaryotic Initiation Factor (eIF)	Neurological Disease
2BAct is a highly selective, and orally active *eIF2B* (eukaryotic initiation factor 2B) activator with an EC₅₀ of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .

HY-149555

DNL343	Eukaryotic Initiation Factor (eIF)	Neurological Disease
DNL343 is a potent, selective, orally active and brain-penetrant activator of eukaryotic initiation factor *eIF2B. DNL343 inhibits the activity of the integrated stress response (ISR) in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B* loss-of-function (LOF) mutant mice. DNL343 can be used in the study of neurodegenerative diseases ^[2] .

HY-RS04248

EIF2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B1 Human Pre-designed siRNA Set A EIF2B1 Human Pre-designed siRNA Set A

HY-RS04249

EIF2B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B2 Human Pre-designed siRNA Set A EIF2B2 Human Pre-designed siRNA Set A

HY-RS04250

EIF2B3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B3 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B3 Human Pre-designed siRNA Set A EIF2B3 Human Pre-designed siRNA Set A

HY-RS04251

EIF2B4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B4 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B4 Human Pre-designed siRNA Set A EIF2B4 Human Pre-designed siRNA Set A

HY-RS04252

EIF2B5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B5 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B5 Human Pre-designed siRNA Set A EIF2B5 Human Pre-designed siRNA Set A

HY-P1114

2B-(SP)	GSK-3	Neurological Disease
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-P1114A

2B-(SP) (TFA)	GSK-3	Cancer
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-158198

PRXS571	Others	Neurological Disease
PRXS571 is a potent modulator of the neuronal integrated stress response (ISR) and can be used in neural-related research .

Cat. No.	Product Name	Type

HY-12495A

ISRIB 10+ Cited Publications	Cell Assay Reagents
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of *eIF2B* and recovering the translation, and thus can be used for neurological disorders research ^[2] .

ISRIB

10+ Cited Publications

Cell Assay Reagents

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P1114

2B-(SP)	GSK-3	Neurological Disease
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-P1114A

2B-(SP) (TFA)	GSK-3	Cancer
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3 .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82058

	eIF2B5 Antibody (YA1803) CACH; CLE; eIF 2B; eIF2B; eIF2B5; eIF2BE; eIF2Bepsilon	WB, IHC-P, ICC/IF	Human
	eIF2B5 Antibody (YA1803) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1803), targeting eIF2B5, with a predicted molecular weight of 80 kDa (observed band size: 80 kDa). eIF2B5 Antibody (YA1803) can be used for WB, IHC-P, ICC/IF experiment in human background.

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